METAPHYLAXIS OF UROLITHIASIS BY VEGETABLE MEDICINES

Мочекаменная болезнь является одной из главных проблем современной урологии как наиболее часто встречающаяся патология органов мочевой системы и составляющая 30 - 50% всех больных урологических стационаров. Целью настоящего исследования явилось изучение эффективности применения препарата «Фитолизин» у больных мочекаменной болезнью. В основу исследования положены результаты лечения 160 (85 женщин и 75 мужчин) пациентов, находившихся на стационарном лечение, средний возраст больных составил 42,2±12,4 года, длительность заболевания от 1-3 до 72 часов, размер конкрементов, в том числе и дезинтегрированных фрагментов после дистанционной ударно-волновой литотрипсии и контактно-лазерная литотрипсия варьировал от 0,4 до 0,8 см. Все больные были разделены на две группы. В основную группу вошли 70 больных, получавших помимо традиционной симптоматической терапии (спазмолитики и водная нагрузка) «Фитолизин» по 43 мл 3 раза в день. В контрольной группе (90 больных) проводилась только традиционная терапия. При включение в терапию препарата «Фитолизин» самостоятельное отхождение отмечено у 64(91,4%) больных, частота возникновения почечной колики имело место у 7(10%), лейкоцитурия - у 14(20%), бактериурия - у 10(15%). Применение фитопрепарата «Фитолизин» в составе комплексной терапии, является эффективным методом консервативного лечения больных мочекаменной болезнью и после после дистанционной ударно-волновой литотрипсии и контактно-лазерная литотрипсия в 90,9% случаев в отношении самостоятельного отхождения конкрементов. Urolithiasis is one of the main problems of modern urology as the most common pathology of the urinary system and makes up 30 - 50% of all patients in urological hospitals. The purpose of this study was to study the effectiveness of the use of the drug "Phytolysin" in patients with urolithiasis. The study is based on the treatment results of 160 (85 women and 75 men) patients who were hospitalized, the average age of the patients was 42.2 ± 12.4 years, the duration of the disease from 1-3 to 72 hours, the size of the stones and disintegrated fragments after remote shock wave lithotripsy and contact laser lithotripsy ranged from 0.4 to 0.8 cm. All patients were divided into two groups. The main group included 70 patients who received in addition to the traditional symptomatic therapy (antispasmodics and water load) "Phytolysin" 43 ml 3 times a day. In the control group (90 patients), only traditional therapy was performed. When "Phytolysin" was included in the therapy, independent discharge was observed in 64 (91.4%) patients, the incidence of renal colic occurred in 7 (10%), leukocyturia in 14 (20%), bacteriuria in 10 (15%). The use of the phytopreparation "Phytolysin" as a part of complex therapy is an effective method of conservative treatment of patients with urolithiasis and after remote shock-wave lithotripsy and contact laser lithotripsy in 90.9% of cases with regard to self-discharge of calculi.

Alternative Thermal Processing Technique for Liquid Foods-membrane Processing

Liquid foods are sensitive to temperature and concentration by conventional methods results in product deterioration. Alternative processes, such as freeze concentration, have the drawback with respect to the maximum achievable concentration (only up to 40 to 45°Brix). In recent years membrane processes such as Microfiltration, Ultrafiltration and reverse osmosis are gaining importance for the concentration of liquid foods. Since heat is not involved in this process, it is also called Alternate thermal processing technique. This process can be employed as a pre-concentration step to reduce water load on subsequent processing steps and can be easily scaled up. Liquid foods such as fruit juices are of high nutritive value as they are naturally enriched with minerals, vitamins and other beneficial components required for human health. When extracted from their sources fruit juices have low solid content, color strength and high-water load. Recent advances and developments in this membrane processing used for the concentration of liquid foods are discussed here.

Rheosorbilact in complex intensive therapy of burn toxemia

Background. Thermal injuries primarily cause coagulation necrosis and cell death with vascular thrombosis in the areas of the deepest lesion.Objective. To study the effectiveness of rheosorbilact in infusion therapy during the period of burn toxemia.Materials and Methods. The results of monitoring the daily volume of the injected fluid, infusion therapy and renal excretory activity of 25 patients admitted to the Department of Combustiology of Republican Research Center of Emergency Medicine due to burn injury were studied.Results. The average daily volume of infusion therapy in group 1, FI – 119.4 ± 38.4 units at the age of 27.3 ± 5.6 years, was 76 ± 7 ml/kg per day, in group 2 (50.7 ± 7.1 years), FI – 92.5 ± 20.8 units, the introduction of 64 ± 9 ml/kg was effective, in group 3 (71.3 ± 7.0 years), FI – 86.7 ± 12.8 units, the introduction of an average of 48 ± 11 ml/kg per day was sufficient. In the nonlinear nature of changes in intravenous infusion, 4–5-day periods can be noted, probably due to the current factors that determined the need to increase or decrease infusion therapy. The introduction of rheosorbilact in a volume of 10 ml/kg per day increased the hourly renal excretory activity in all patients during the period of toxemia. The diuretic effect was more pronounced in patients of group 1, which corresponded to a greater volume of water load and the severity of burn injury.Conclusions. The introduction of rheosorbilact in a volume of 10 ml/kg per day increased the hourly renal excretory activity in all patients during the period of toxemia.

Regional Crustal Vertical Deformation Driven by Terrestrial Water Load Depending on CORS Network and Environmental Loading Data: A Case Study of Southeast Zhejiang

Monitoring regional terrestrial water load deformation is of great significance to the dynamic maintenance and hydrodynamic study of the regional benchmark framework. In view of the lack of a spatial interpolation method based on the GNSS (Global Navigation Satellite System) elevation time series for obtaining terrestrial water load deformation information, this paper proposes to employ a CORS (Continuously Operating Reference Stations) network combined with environmental loading data, such as ECMWF (European Centre for Medium-Range Weather Forecasts) atmospheric data, the GLDAS (Global Land Data Assimilation System) hydrological model, and MSLA (Mean Sea Level Anomaly) data. Based on the load deformation theory and spherical harmonic analysis method, we took 38 CORS stations in southeast Zhejiang province as an example and comprehensively determined the vertical deformation of the crust as caused by regional terrestrial water load changes from January 2015 to December 2017, and then compared these data with the GRACE (Gravity Recovery and Climate Experiment) satellite. The results show that the vertical deformation value of the terrestrial water load in southeast Zhejiang, as monitored by the CORS network, can reach a centimeter, and the amplitude changes from −1.8 cm to 2.4 cm. The seasonal change is obvious, and the spatial distribution takes a ladder form from inland to coastal regions. The surface vertical deformation caused by groundwater load changes in the east–west–south–north–central sub-regions show obvious fluctuations from 2015 to 2017, and the trends of the five sub-regions are consistent. The amplitude of surface vertical deformation caused by groundwater load change in the west is higher than that in the east. We tested the use of GRACE for the verification of CORS network monitoring results and found a relatively consistent temporal distribution between both data sets after phase delay correction on GRACE, except for in three months—November in 2015, and January and February in 2016. The results show that the comprehensive solution based on the CORS network can effectively improve the monitoring of crustal vertical deformation during regional terrestrial water load change.

Optimization Design and Analysis of Single-Stage Mixed Refrigerant Liquefaction Process

Small-scale natural gas liquefaction processes have several clear advantages, particularly in the exploitation of ‘unconventional’ natural gas (NG) from sources such as difficult-to-access and offshore gas fields. Moreover, conventional liquefaction processes have a number of disadvantages such as high energy consumption, large cooling loads required in the refrigeration cycle, and non-uniform matching of cold and hot flows in liquified natural gas (LNG) heat exchanger (HE). The main objective of this study was to optimize the most commonly used mixed refrigerant process. The liquefaction performance of the optimized process was analyzed and the influence of gas parameters on the power consumption, exergy loss, freezing mixture circulation, and cooling water load were investigated. The results show that compressor power consumption can be reduced by 29.8%, the cooling water load can be reduced by 21.3%, and the system exergy efficiency can be increased by 41% with the optimized process. Furthermore, throttling and compression of the freezing mixture were increased during the refrigeration stage. It can be concluded that reducing the feed gas temperature and increasing the feed gas pressure can reduce the total power consumption, exergy loss, freezing mixture circulation, and cooling water load, which can significantly improve liquefaction performance.

Experimental Centrifuge Study of the Effects of Valley Topography on the Behavior of a Concrete Face Rockfill Dam

The recent focus on water conservancy projects globally has resulted in the construction of increased numbers of concrete face rockfill dams in narrow valleys. However, valley topography impacts the deformation of a dam and further influences the distribution of stress and position of cracks on the face slab. This study conducted two centrifuge experiments to study the influence of the valley topography on the behavior of a concrete face rockfill dam from construction to impoundment. Experimental models of concrete face slab sand-gravel dams with “U”-type and “V”-type valley topographies were established. The settlement of the dam crest, the displacement of the upstream slope of the dam, and the stress on both sides of the face slab were observed. The experiment also represented the cracking of the face slab during impoundment. The results showed that the “V”-type valley topography effectively reduced the progression of dam crest settlement and influenced stress on the slab resulting from impounded water pressure. Furthermore, the flexural form of the face slab in the “U”-type valley topography took on a “D” shape and cracks progressively developed on the face slab with increased water load. The flexural form of the face slab in the “V”-type valley topography showed a “B” shape, and cracks occurred under a particular water impoundment pressure.

Changes in amygdalar functional connectivity following the water load symptom provocation task (WL-SPT) in youth with functional abdominal pain disorders

Pediatric functional abdominal pain disorders (FAPD) are highly prevalent, difficult to diagnose and challenging to treat. The brain mechanisms supporting FAPD remain poorly understood. This investigation examined the neuromechanisms of FAPD during a well-tolerated visceral pain induction task, the water load symptom provocation task (WL-SPT). Youth between the ages of 11 and 17 years participated. Functional connectivity (FC) was examined via the Blood Oxygenation Level Dependent (BOLD) effect using the left and right amygdala (AMY) as seed regions. Relationships of the time courses within these seeds with voxels across the whole brain were evaluated. Arterial spin labeling (ASL) was used to assess regional brain activation by examining cerebral blood flow. Increased FC between the left AMY with regions associated with nociceptive processing (e.g., thalamus), and right AMY FC changes with areas associated with cognitive functioning (dorsolateral prefrontal cortex) and the default mode network (DMN; parietal lobe) were observed in youth with FAPD following the WL-SPT. These changes were related to changes in pain unpleasantness. AMY FC changes post WL-SPT were also related to changes in pain intensity. AMY FC with the DMN in youth with FAPD also differed from healthy controls. Global CBF changes were also noted between FAPD and controls, but no significant differences in grey matter were detected either between groups or during the WL-SPT in youth with FAPD. Findings confirm youth with FAPD have changes in brain connectivity that could support the development of biomarkers to enhance understanding of the mechanisms of pain and treatment response.

Reference values for the water load test in healthy school children and adolescents

Background and study aim: The water load test (WLT) is an easy and cheap tool, useful in evaluating gastric accommodation and visceral hypersensitivity. This test can be used in diagnosing functional gastrointestinal disorders, like functional dyspepsia. Our main aim was to propose reference values for the WLT. Our secondary aim was to correlate the water volume drunk with the students’ gender, age, and anthropometric measures. Patients and methods: We performed the WLT in students aged 8 to 17 years. Students drank water ad libitum for 3 minutes or until pain, satiety or vomiting occurred. We correlated anthropometric variables with water volumes drunk. Upper and lower limit for the maximum tolerated volume were calculated as the 5th and 95th percentile. Pain and nausea were recorded before and after the test. Results: We evaluated 99 students, with a median age (inter quartile range) of 11 years 10-13 years) and 55.6 % were girls. Median water volume drank was 380 ml (190-540 ml). Boys (523 ml, interquartile range : 275-760 ml) drank more water than girls (380 ml, interquartile range : 190-570 ml) (p = 0.016). There was a significant correlation between water volume drank and students´ age, weight, height, and body mass index. Of the students that completed the WLT, 22.2 % had nausea and 30.3 % had mild abdominal pain after the test. Conclusions: We proposed reference values for the WLT in children aged 8 to 17 years. Adverse effects are minimal, it is safe to perform, and well tolerated.

FC 054FUNCTIONAL SODIUM MAGNETIC RESONANCE IMAGING OF THE HUMAN KIDNEY

Background and Aims Maintenance of a cortico-medullary concentration gradient (CMG) required for urine concentration, is one of most important tubular function. However, we are lacking of functional tubular parameters to explore this function. The only tool available to assess it currently, is urinary osmolarity that is an indirect and nonspecific maker of CMG. In this study, we explore the ability of 23NaMRI in measuring 1) the dynamics of CMG for the first time compared to urinary osmolarity after a water load 2) the CMG in kidney disease. Method We conducted an exploratory pilot study for 10 healthy controls with water load then 5 cardiorenal patients with kidney disease. 1) Healthy controls were asked to be fasting since midnight. Urines sample were collected to measure fasting osmolarity and a first MRIscan were performed to acquire baseline anatomical and sodium images. Once the baseline was completed, healthy participants were asked to ingest water (15 mL/kg) within 15 minutes. Four subsequent sodium pictures were acquired an hour after water ingestion. Urine samples were obtained after each sodium acquisition every 15 min during one hours. 2) Cardiorenal patients underwent an MRI scan, provided a spot urine sample and have blood work collected. All MR experiments were carried out on a GE MR750 3T (GE Healthcare, WI). A custom-built two-loop (18cm in diameter) butterfly radiofrequency surface coil tuned for 23Na frequency (33.786 MHz) was used to acquire renal 23Na images. Results Mean age of the 10 healthy controls was 41.8 ± 15.3 years, mean body mass index (BMI) was 24.3 ± 3.8 kg/m2. Mean water intake was 1092 ± 233 mL, total water excreted was 1250 ± 301 mL . Mean age of the 5 cardiorenal patients was 76.6 ± 12.2 years, mean BMI was 28.1 ± 6.9 kg/m2. eGFR was 54 ± 37 mL/min/1.73m2. Urinary osmolarity was 498 ± 145 mosm/L and medulla/cortex ratio was 1.35 ± 0.11. Sodium imaging was successfully acquired in all volunteers. In the morning fasting, medulla/cortex ratio was 1.55 ± 0.11 regarding to a urinary osmolarity to 814 ± 121 mosm/L. Mean ± SD fasting urinary osmolarity dropped significantly to 73 ± 14 mosm/L for maximal dilution, p=0.001. Mean medulla/cortex ratio dropped significantly to 1.31 ± 0.09 mosm/L for maximal dilution, p=0.002. Figure 1 displays changes of 23NaMRI pictures before (A) then 1h (B), 1H15 (C), 1h30 (D) and 1h45 (E) after a water load. Urinary osmolarity and medulla/cortex ratio are significantly correlated, r=0.54, p=0.0001. We measured corticomedullary gradient in cardiorenal patient with different level of eGFR to show the ability and feasibility to measure this gradient in pathological settings. We were able to measure medulla/cortex ratio in patients with CKD with a mean SNR of 20.45 ± 9.45. Conclusion We explored CMG dynamically every 15 min and we were able to discriminate significant changes after a water load. We were also able to provide efficient 23NaMRI pictures in cardiorenal patients with kidney disease. CMG exploration would provide a relevant assessment of tubular dysfunction independently of glomerular alteration and thus could be of prognostic value.