organ transplant recipients
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2022 ◽  
Author(s):  
Jessica Hedvat ◽  
David M. Salerno ◽  
Danielle Kovac ◽  
Jenna L. Scheffert ◽  
Heather Corbo ◽  
...  

Author(s):  
Danly Omil-Lima ◽  
Erin Jesse ◽  
Karishma Gupta ◽  
Nicholas Sellke ◽  
Wade Muncey ◽  
...  

Vaccines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 95
Author(s):  
Orly Efros ◽  
Roi Anteby ◽  
Mirit Halfon ◽  
Eshcar Meisel ◽  
Eyal Klang ◽  
...  

Solid organ transplant recipients were demonstrated to have reduced antibody response to the first and second doses of the COVID-19 mRNA vaccine. This review evaluated published data on the efficacy and safety of the third dose among solid organ transplant recipients. We performed a systematic search of PubMed, EMBASE, and Web of Science to retrieve studies evaluating the efficacy of the third dose of anti-SARS-CoV-2 vaccines in adult solid organ transplant recipients. Serologic response after the third vaccine was pooled using inverse variance and generalized linear mixed and random-effects models. Seven studies met our inclusion criteria. A total of 853 patients received the third dose. Except for one randomized controlled trial, all studies were retrospective in design. Following the third COVID-19 vaccine dose, antibody response occurred in 6.4–69.2% of patients. The pooled proportion of antibody response rate after the third vaccine was 50.3% (95% confidence interval (CI): 37.1–63.5, I2 = 90%). Five papers reported the safety profile. No severe adverse events were observed after the third vaccine dose. In conclusion, a third dose of the SARS-CoV-2 mRNA vaccine in solid organ transplant recipients is associated with improved immunogenicity and appears to be safe. Nevertheless, a significant portion of patients remain seronegative.


2022 ◽  
Author(s):  
Kevin J. Downes ◽  
Anna Sharova ◽  
Craig L. K. Boge ◽  
Daniel Vader ◽  
Marina Mitrou ◽  
...  

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