allylic bromide
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2020 ◽  
Vol 7 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Shengqing Ye ◽  
Kaida Zhou ◽  
Pornchai Rojsitthisak ◽  
Jie Wu

Metal-free insertion of sulfur dioxide with aryl iodides and silyl enolates or allylic bromide under ultraviolet irradiation at room temperature is accomplished. This protocol provides a convenient route to sulfonated cyclic compounds under mild conditions.


2018 ◽  
Vol 54 (71) ◽  
pp. 9893-9896 ◽  
Author(s):  
Izuru Tsuchimochi ◽  
Yuta Kitamura ◽  
Hiroshi Aoyama ◽  
Shuji Akai ◽  
Keiyo Nakai ◽  
...  

A new synthetic approach to (−)-agelastatin A has been established through the strategic implementation of brominative olefin transposition of a silyl enol ether and subsequent SH2′ radical azidation of the resultant allylic bromide.


2018 ◽  
Vol 16 (39) ◽  
pp. 7143-7151 ◽  
Author(s):  
Xianwei Li ◽  
Tianzhang Wang ◽  
Yu-Jing Lu ◽  
Shaomin Ji ◽  
Yanping Huo ◽  
...  

An oxidative cascade that involves multicomponent reaction comprising a terminal alkyne, 2-amino N-heterocycle, benzyl or allylic bromide with molecular oxygen, delivering densely functionalized imidazo fused heterocycles, is achieved.


Author(s):  
Douglass F. Taber

Günter Helmchen of the Ruprecht-Karls-Universität Heidelberg set (Organic Lett. 2010, 12, 1108) the absolute configuration of 3 by Ir*-mediated coupling of 1 with 2. Diastereoselective Pauson-Khand cyclization then led to (-)-α-kainic acid 5. Till Opatz, now at the Johannes Gutenberg-Universität Mainz, showed (Organic Lett. 2010, 12, 2140) that the product from the Dibal reduction of 6 could be condensed with the amine 7 without epimerization. Kim cyclization then directly delivered the pentacyclic alkaloid (+)-tylophorine 9. The interesting dimeric alkaloid lycoperine A 13 was recently isolated from the Japanese club moss Lycopodium hamiltonii. Scott D. Rychnovsky of the University of California, Irvine, prepared (Organic Lett. 2010, 12, 72) 12 by double alkylation of the bis-nitrile 11 with the enantiomerically pure allylic bromide 10. Although the projected reductive decyanation of 12 failed, hydrolysis followed by diastereoselective reductive amination successfully gave 13. Retrosynthetic analysis of fluvirucinine A2 16 could lead to an acyclic amino acid, which could be cyclized to the macrolactam. Young-Ger Suh of Seoul National University took (Organic Lett. 2010, 12, 2040) a different approach, building up the 14-membered ring system by two four-carbon ring expansions, beginning with an enantiomerically pure piperidine precursor. The second of these enolate-based aza-Claisen ring expansions is illustrated in the conversion of 14 to 15. Richmond Sarpong of the University of California, Berkeley, faced (J. Am. Chem. Soc. 2010, 132, 5926) a different sort of challenge in the synthesis of the dimeric Lycopodium alkaloid complanadine A 19. Even with established access to monomers such as 17 and its precursors, it was not clear how the 5-position of the pyridine ring could be selectively activated for bond formation. The solution to this dilemma was found in the work of Hartwig. Following that precedent, Ir-catalyzed activation of 17 converted it cleanly into the borinate 18, which could then be coupled with a pyridone triflate to complete the synthesis of 19.


ChemInform ◽  
2010 ◽  
Vol 28 (22) ◽  
pp. no-no
Author(s):  
I. BELTAIEF ◽  
R. BESBES ◽  
H. AMRI ◽  
J. VILLIERAS

ChemInform ◽  
2010 ◽  
Vol 30 (41) ◽  
pp. no-no
Author(s):  
Hyo Won Lee ◽  
Yong Deog Hong ◽  
Ihl-Young Choi Lee

ChemInform ◽  
2010 ◽  
Vol 32 (26) ◽  
pp. no-no
Author(s):  
Weike Su ◽  
Jinghua Li ◽  
Yongmin Zhang
Keyword(s):  

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