dirigent proteins
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2021 ◽  
Author(s):  
Guolong Yu ◽  
Jianan Zou ◽  
Jinhui Wang ◽  
Rongsheng Zhu ◽  
Zhaoming Qi ◽  
...  

The Analyst ◽  
2021 ◽  
Author(s):  
Mowei Zhou ◽  
Joseph A Laureanti ◽  
Callum Bell ◽  
Mi Kwon ◽  
Qingyan Meng ◽  
...  

The discovery of dirigent proteins (DPs) and their functions in plant phenol biochemistry was made over two decades ago with Forsythia × intermedia. Stereo-selective, DP-guided, monolignol-derived radical coupling in vitro...


2020 ◽  
Vol 295 (33) ◽  
pp. 11584-11601 ◽  
Author(s):  
Qingyan Meng ◽  
Syed G. A. Moinuddin ◽  
Sung-Jin Kim ◽  
Diana L. Bedgar ◽  
Michael A. Costa ◽  
...  

The biochemical activities of dirigent proteins (DPs) give rise to distinct complex classes of plant phenolics. DPs apparently began to emerge during the aquatic-to-land transition, with phylogenetic analyses revealing the presence of numerous DP subfamilies in the plant kingdom. The vast majority (>95%) of DPs in these large multigene families still await discovery of their biochemical functions. Here, we elucidated the 3D structures of two pterocarpan-forming proteins with dirigent-like domains. Both proteins stereospecifically convert distinct diastereomeric chiral isoflavonoid precursors to the chiral pterocarpans, (–)- and (+)-medicarpin, respectively. Their 3D structures enabled comparisons with stereoselective lignan– and aromatic terpenoid–forming DP orthologs. Each protein provides entry into diverse plant natural products classes, and our experiments suggest a common biochemical mechanism in binding and stabilizing distinct plant phenol–derived mono- and bis-quinone methide intermediates during different C–C and C–O bond–forming processes. These observations provide key insights into both their appearance and functional diversification of DPs during land plant evolution/adaptation. The proposed biochemical mechanisms based on our findings provide important clues to how additional physiological roles for DPs and proteins harboring dirigent-like domains can now be rationally and systematically identified.


2017 ◽  
Vol 68 (13) ◽  
pp. 3287-3301 ◽  
Author(s):  
Candelas Paniagua ◽  
Anna Bilkova ◽  
Phil Jackson ◽  
Siarhei Dabravolski ◽  
Willi Riber ◽  
...  

2016 ◽  
Vol 101 (5) ◽  
pp. 2021-2032 ◽  
Author(s):  
Isabelle Effenberger ◽  
Michael Harport ◽  
Jens Pfannstiel ◽  
Iris Klaiber ◽  
Andreas Schaller

2015 ◽  
Vol 54 (49) ◽  
pp. n/a-n/a ◽  
Author(s):  
Isabelle Effenberger ◽  
Bin Zhang ◽  
Ling Li ◽  
Qiang Wang ◽  
Yuxiu Liu ◽  
...  
Keyword(s):  

2015 ◽  
Vol 54 (49) ◽  
pp. 14660-14663 ◽  
Author(s):  
Isabelle Effenberger ◽  
Bin Zhang ◽  
Ling Li ◽  
Qiang Wang ◽  
Yuxiu Liu ◽  
...  
Keyword(s):  

2012 ◽  
Vol 287 (41) ◽  
pp. 33957-33972 ◽  
Author(s):  
Kye-Won Kim ◽  
Syed G. A. Moinuddin ◽  
Kathleen M. Atwell ◽  
Michael A. Costa ◽  
Laurence B. Davin ◽  
...  
Keyword(s):  

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