Responsiveness to students’ mathematical thinking is a characteristic of classroom discourse that reflects the extent to which students’ mathematical ideas are present, attended to, and taken up as the basis for instruction. Using the Mathematically Responsive Interaction (MRI) Framework and data from 11 middle-grades classrooms, we illustrate varied enactments of responsiveness and describe fluctuations in and relationships among different components of responsiveness. We found positive associations between different components of responsiveness, but they were not entirely predictive of one another. Individual classrooms appeared more or less responsive depending on which component was foregrounded. Our findings offer a more comprehensive characterization of responsiveness that documents the intertwined nature of teacher moves and student contributions during all whole-class instruction.