La dot dagara : Les implications herméneutiques et intermédiales

Some Africans more specifically some dagara, no more want nowadays that their future husbands pay the traditional dowry. Their parents think the contrary. The absence of these social principles deprives this human association of its title of sacred union. Certain antagonisms of the two different worlds appear of which one is inclined to westernization and the other to africanization. This tensive atmosphere led us to the reflection on ‘The dagara dowry’. The problem that it creates is expressed by these terms: be known, explained, well interpreted to the service of the two rival parties. That is the reason of the following sub-titles:”The hermeneutic and intermedial implications”. Our exegetics is based on the behavioral semiotic of the signs and the dagara oral discourses.

Design and Implementation of COVID19 Safety Amalgamation

This article gives an explanation about constructing the system that helps in preventing the open out of the virus and also minimizes human association with possible and reduces costs associated with hiring employees for manual thermal screening and readings. Thus, automating the tasks such as automatic temperature screening, face mask detection using image processing methods, and automatic hand sanitizer dispenser with the help of the Internet of Things (IoT). In a world battling against novel coronavirus disease, technology has been a lifesaver. This amalgamate system has features like a quick and efficient contactless automatic temperature screening and automatic mask detection along with an automatic hand sanitization system which will be a prototype built at a reduced cost which will helpfully be ensuring safety for Corona Virus Disease (COVID19) Pandemic.

Infant inhibited temperament in primates predicts adult behavior, is heritable, and is associated with anxiety-relevant genetic variation

An anxious or inhibited temperament (IT) early in life is a major risk factor for the later development of stress-related psychopathology. Starting in infancy, nonhuman primates, like humans, begin to reveal their temperament when exposed to novel situations. Here, in Study 1 we demonstrate this infant IT predicts adult behavior. Specifically, in over 600 monkeys, we found that individuals scored as inhibited during infancy were more likely to refuse treats offered by potentially-threatening human experimenters as adults. In Study 2, using a sample of over 4000 monkeys from a large multi-generational family pedigree, we demonstrate that infant IT is partially heritable. The data revealed infant IT to reflect a co-inherited substrate that manifests across multiple latent variables. Finally, in Study 3 we performed whole-genome sequencing in 106 monkeys to identify IT-associated single-nucleotide variations (SNVs). Results demonstrated a genome-wide significant SNV near CTNNA2, suggesting a molecular target worthy of additional investigation. Moreover, we observed lower p values in genes implicated in human association studies of neuroticism and depression. Together, these data demonstrate the utility of our model of infant inhibited temperament in the rhesus monkey to facilitate discovery of genes that are relevant to the long-term inherited risk to develop anxiety and depressive disorders.

Discrete ripples reflect a spectrum of synchronous spiking activity in human association cortex

Direct brain recordings have provided important insights into how persistent oscillatory activity support human memory retrieval, but the extent to which transient fluctuations in intracranial EEG (iEEG) captures the dynamic coordination of underlying neurons involved in memory processing remains unclear. Here, we simultaneously record iEEG, local field potential (LFP), and single unit activity in the human temporal cortex. We demonstrate that cortical ripples contribute to broadband high frequency activity and exhibit a spectrum of amplitudes and durations related to the amount of underlying neuronal spiking. Ripples in the macro-scale iEEG are related to the number and synchrony of ripples in the micro-scale LFP, which in turn are related to the synchrony of neuronal spiking. Our data suggest that neural activity in the human cortex is organized into dynamic, discrete packets of information.

Strategies to lower fibroblast growth factor-23 bioactivity

Fibroblast growth factor-23 (FGF23) is a circulating hormone derived from the bone whose release is controlled by many factors and exerts a multitude of systemic actions. There are congenital and acquired disorders of increased and decreased FGF23 levels. In chronic kidney disease, elevations of FGF23 levels can be 1000-fold above the upper physiological limit. It is still under debate whether this high FGF23 in chronic kidney disease is a biomarker or causally related to morbidity and mortality. Data from human association studies supports pathogenicity, while experimental data is less robust. Knowledge of the biology and pathobiology of FGF23 have generated a whole plethora of means to reduce FGF23 bioactivity at many levels that will be useful for therapeutic translations. This manuscript summarize these approaches and addressed several critical questions that still need to be addressed.