cardiac membrane
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Author(s):  
Shin-Haw Lee ◽  
Da Hye Kim ◽  
Uros Kuzmanov ◽  
Anthony O Gramolini

Cardiovascular diseases remain the most rapidly rising contributing factor of all-cause mortality and the leading cause of inpatient hospitalization worldwide, with costs exceeding $30 billion dollars annually in North America. Cell surface and membrane associated proteins play an important role in cardiomyocyte biology and are involved in the pathogenesis of many human heart diseases. In cardiomyocytes, membrane proteins serve as critical signaling receptors, Ca2+ cycling regulators, and electrical propagation regulators, all functioning in concert to maintain spontaneous and synchronous contractions of cardiomyocytes. Membrane proteins are excellent pharmaceutical targets due to their uniquely exposed position within the cell. Perturbations in cardiac membrane protein localization and function have been implicated in the progression and pathogenesis of many heart diseases. However, previous attempts at profiling the cardiac membrane proteome have yielded limited results due to poor technological developments for isolating hydrophobic, low abundant membrane proteins. Comprehensive mapping and characterization of the cardiac membrane proteome thereby remains incomplete. This review will focus on recent advances in mapping the cardiac membrane proteome and the role of novel cardiac membrane proteins in the healthy and diseased heart.


Author(s):  
Matthieu Pelletier-Galarneau ◽  
Yoann Petibon ◽  
Chao Ma ◽  
Paul Han ◽  
Sally Ji Who Kim ◽  
...  

2017 ◽  
Vol 26 ◽  
pp. S156-S157
Author(s):  
S. Nicolaides ◽  
J. Gonsalves
Keyword(s):  

Kardiologiia ◽  
2014 ◽  
Vol 12_2014 ◽  
pp. 29-36 ◽  
Author(s):  
E.M. Gupalo Gupalo ◽  
O.V. Stukalova Stukalova ◽  
M.M. Rogova Rogova ◽  
N.A. Mironova Mironova ◽  
T.A. Malkina Malkina ◽  
...  

2014 ◽  
Vol 107 (6) ◽  
pp. 1313-1317 ◽  
Author(s):  
Daisuke Sato ◽  
Daniel C. Bartos ◽  
Kenneth S. Ginsburg ◽  
Donald M. Bers

2014 ◽  
Vol 115 (1) ◽  
pp. 68-78 ◽  
Author(s):  
Jerry Curran ◽  
Michael A. Makara ◽  
Sean C. Little ◽  
Hassan Musa ◽  
Bin Liu ◽  
...  

2014 ◽  
Vol 106 (2) ◽  
pp. 531a
Author(s):  
Daisuke Sato ◽  
Donald M. Bers

2013 ◽  
Vol 104 (2) ◽  
pp. 299a-300a
Author(s):  
Xiaoqiong Dong ◽  
Ji Li ◽  
Christine B. Karim ◽  
David D. Thomas

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