Changing dynamics in responsible and sustainable business comes as a must in the post-COVID-19 era, while energetic, influential, and powerful transformational leaders represent the vital solution to ensuring creativity in business and a luminous future for organizations worldwide. On the one hand, the newest challenges faced by companies due to the COVID-19 pandemic are analyzed, while, on the other hand, the dominant traits of leaders are displayed in an attempt to determine the successful mix between creative actions, human resources, innovation, intangible assets, intellectual capital, research, technological advancement, and visionary managerial business processes. The study shows that transformational leaders' general focus should be on the amazing benefits derived from addressing fundamental issues, such as the well-being of individuals, the health of the planet, reaching the Sustainable Development Goals (SDGs), bringing circular economy (CE), artificial intelligence (AI), and smart cities (SC) closer to human beings' vital needs.