Recent revisions to USDA FSIS compliance and safe harbor guidelines for ready-to-eat meat and poultry products addressed process humidity requirements. Given the lack of prior data for impingement-cooked products, this project aimed to evaluate the impact of process humidity on Salmonella lethality at the product core and surface, and compliance of the results with USDA FSIS lethality performance standards. Whole muscle beef strips, ground beef patties, whole muscle chicken breast fillets, and breaded ground chicken patties were inoculated with an 8-serovar cocktail of Salmonella. Beef and chicken samples were cooked in a pilot-scale moist-air impingement oven to a core temperature of 70.0 or 72.8°C, respectively, immediately quenched in liquid nitrogen, and dissected to obtain core and surface samples. Variables included oven temperature (218, 232°C), air velocity (0.7 and 2.8 m/s), and oven humidity (0.7, 15, 30, or 70% moisture by volume (% v/v)). Additional treatments were performed to examine the impact of supplemental critical control processes, such as increased endpoint temperature, post-oven carryover time, and pre- or post-oven steam treatments. Salmonella reductions of >7 log were reliably achieved in chicken patties regardless of the processing variables; however, none of the treatments reliably ensured >6.5 log reductions of Salmonella in ground beef. A majority of whole-muscle samples failed to meet the required performance lethality when processed at 0.7% v/v; however, Salmonella inactivation was significantly improved (P < 0.05) at oven humidities of > 30% v/v. Dry oven conditions achieved greater Salmonella lethality at the core than at the surface for multiple products (P < 0.05). The efficacies of minimal and supplemental critical controls were product-, process-, and humidity-dependent (P < 0.05). Overall, process humidity and product variability should be considered in regulatory requirements and process validations.