As a new logistics mode, overseas warehouse can save transportation time for cross-border logistics and also solve the problem of customer return and exchange as soon as possible. This paper takesmanufacturing cross-border e-commerce enterprise logistics as the starting point, considering cost, market, environment, society and other factors, establishes a multi-objective overseas warehouse location model to set up alternatives, analyzes the location model by analytic hierarchy process, selects the optimal solution of overseas warehouse location in the alternatives, and verifies the method by an example. Finally, it puts forward targeted suggestions for manufacturingcross-border e-commerce enterprises to establish overseas warehouses, and then promotes the new logistics mode of manufacturingcross-border e-commerce overseas warehouses to mature and standardize.