The purpose of the article is to demonstrate the methodological effectiveness of one of the directions in developing the philosophy of science – cultural and historical epistemology. Cultural-historical epistemology does not pretend at all to be any radical epistemological originality but offers a general view of science as a part of intellectual culture, where both individual historical cases and broad sociological generalizations find their methodologically significant place. The authors believe that it is the development of methodological norms capable of determining the fundamental parameters and strategies of scientific research that is now the central task of the philosophy of science. One of the characteristic forms of organization of modern advanced science is interdisciplinary research programs that involve the joint activities of large research teams. This fact raises a critical question about the mutual understanding of specialists from different disciplines and, accordingly, about the development of methodological norms that can determine the generally accepted parameters of the reproducibility of cognition results. Thus, in the center of attention of the philosophy of science, epistemological plots are put forward, one way or another connected with a specific understanding of the phenomenon of communication in science. Moreover, according to the authors, in these philosophical and methodological searches, it is essential to overcome, on the one hand, the inclination to conceptual design that leads away from the real methodological needs of science and, on the other hand, straightforward sociologization and equally direct historicization of science. These approaches are fraught with relativization of the very idea of scientific knowledge as a rational phenomenon of culture. The authors of the article believe that in modern conceptual trends in the philosophy of science, it is necessary to accentuate quite traditional epistemological principles, which in their updated edition make it possible to activate, or, as it were, to revive the methodological functions of the philosophy of science that are partially lost today. Justifying this approach, the authors turn to the epistemological trend, which for two decades has been developed based on the traditions of Russian philosophy of the first half of the 20th century.