Abstract: To improve the beam pointing accuracy of PW laser facility and reduce the optical axis deviation caused by the deflection amplitude response deviation of the confocal lens of spatial filter for microvibration action, an Optomechanical coupling vibration active control theory is proposed to make the peak value of output optical angle response lower than the pointing threshold value by 0.2 µrad. To establish an Optomechanical coupling vibration active control system, the active control parameters are introduced into the beam transmission matrix of the Optomechanical coupling system. The active control parameters and the peak value of the output light angle response are linked point to point. The algorithm flow of the active control system is designed, the control rules are established, and the control effect is verified. The results show that the peak value of the output optical angle response of the spatial filter decreases by 98.13%, and the attenuation is nearly two orders of magnitude after the active control, which effectively improves the convergence accuracy of the beam pointing of the spatial filter of the PW laser facility, and realizes the beam pointing control under the broadband excitation, and the control result is consistent with the expectation.