<p>Basement/cover interfaces are important transfer zones for hydrothermal fluids responsible for ore deposition, such as U and Pb-Zn deposits. Unconformities are peculiarly mixing zone where basement-derived fluids encounter sedimentary- and/or meteoric-derived fluids; leading to precipitation of these ores. Fluids are channelized by permeability contrast, i.e. impermeable barriers, until being trapped in porous units, i.e. intrinsic porosity and/or secondary porosity (dissolution and karstification process). In this configuration fracturing channelize the fluid flow by breaking impermeable barriers allowing external fluids to enter and react with the rocks (precipitation and/or dissolution). In this way, structural studies are crucial to highlight the fracture network and the potential of geological units to be good reservoirs.</p><p>In France, many occurrences of sediment-hosted deposits are known in Mesozoic basins (i.e. Aquitaine and Paris Basin) especially above the Variscan basement (Morvan district, SW Massif Central district, Poitou High district). The Vend&#233;e coast deposit (South Armorican Massif, France) is known for two Pb-Zn(-Ag) occurrences located in Liassic sediments overlying the Variscan basement. Previous works show that, during the Upper Jurassic extensional event (NNE-SSW horizontal stretching), the ore deposition results from the mixing of two different fluids: (1) low temperature brines following a horizontal path from evaporite to basin borders within Liassic sediments along the unconformity, (2) a high temperature and low salinity fluid rising up through the basement from several kilometres depth by a probable vertical pathway.</p><p>However, the permeability architecture leading to such mixing remains poorly constrained. The Vend&#233;e ore deposits present favourable outcrop conditions to study the structural control of the fluid plumbing system along the basement/cover unconformity. Structural studies assisted by drone imagery coupled with the characterization of the alteration-mineralization pattern show that:</p><p>(1) Horizontal path for basin brines is controlled by the impermeable barrier of the Toarcien layer overlying Liassic hosting karsts.</p><p>(2) Vertical path of basement-derived fluids is enhanced by new faults and inherited fractures, respectively generated and reopened by the Jurassic extension.</p><p>(3) Relative abundance of faults and veins in the Liassic sedimentary cover and the basement is consistent with a mechanical decoupling in a context of fluid overpressure.</p>