The Dynamics of Malaria Clinical Symptoms with very Strong Emphasis on Asymptomatic Malaria

In the developed world, malaria is a dangerous parasite that contributes to high morbidity and mortality. The disease is variable and its clinical presence varies from extreme to complex, normal, and difficult malaria, asymptomatic malaria. Malaria pathogenesis is complex. Our current research was conducted at Mayo Hospital, Lahore from May 2019 to February 2020. Despite several clinical severities trials the disorder is still poorly known for asymptomatic malaria infection. Malaria remains a problem for asymptomatic malaria, as it has a significant impact on the dynamic of transmission. In order to develop various therapeutic results, a thorough understanding of the relationship between hosts and parasites is important. Problems and obstacles to asymptomatic malaria study and management are addressed in this study. Man and parasite are identified and methods for management and recovery are presented for differential clinical outcomes. They are exposed to disease prevention. In the context of prospective studies to create more efficient malaria prevention methods, important lacunae in the understanding of asymptomatic malaria are further illustrated. Keywords: Malaria Clinical Symptoms, Strong Emphasis, Asymptomatic Malaria.

Miniscrew-assisted rapid palatal expander (MARPE) therapeutic results: A review

Background: One of the most common maxillary abnormalities is transverse deficiency, which can be a contributory factor in malocclusions. There are some evidence of successful non-surgical treatment of this type of discrepancy after puberty by using maxillary expansion techniques. The Miniscrew-assisted rapid palatal expander (MARPE) method is a newly introduced method that has attracted the interest of many orthodontists. This study aimed to evaluate the therapeutic results of this technique in a systematic review. Method: In this study, various databases including PubMed, Scopus, and ISI (Web of science) were queried with proper keywords, provided by PICO strategy of research, from 1980 to December 2020. Relevant articles were collected with restrictions on the English language. The full text of papers with all inclusion criteria was assessed. The therapeutic outcomes of MARPE were evaluated in the selected studies. Results: A total of 14 studies were included in the systematic review. Totally, 5 case report studies, 8 retrospective studies, and 1 case series study were reviewed. Cone-beam computed tomography was used as an outcome measure in all studies. In all reviewed studies, maxillary expansion occurred with high success rates in patients. Moreover, respiratory characteristics were also assessed in two studies measuring respiratory muscle strength, airflow and nasal and nasopharyngeal airway volume, showing benefits of MARPE. A study also examined three-dimensional soft tissue stereophotogrammetry. Based on these studies, the indication for using this method was a maxillary transverse deficiency as well as upper and lower arches crowding. No serious complications were reported in any of the reviewed studies. However, most studies did not perform long-term follow-ups and the age range of the subjects was mainly between 12 and 24 years. MARPE has been suggested as a treatment modality for correction of maxillary transverse deficiency in young adults but patients under the age of 14 may also benefit from this treatment in special conditions. Conclusion: A general review of the results of studies showed the high efficiency of MARPE technique in correcting maxillary transverse deficiency.

Pharmaco-Magnetic Resonance as a Tool for Monitoring the Medication-Related Effects in the Brain May Provide Potential Biomarkers for Psychotic Disorders

The neurodegenerative and neurodevelopmental hypotheses represent the basic etiological framework for the origin of schizophrenia. Additionally, the dopamine hypothesis, adopted more than two decades ago, has repeatedly asserted the position of dopamine as a pathobiochemical substrate through the action of psychostimulants and neuroleptics on the mesolimbic and mesocortical systems, giving insight into the origin of positive and negative schizophrenic symptoms. Meanwhile, cognitive impairments in schizophrenia remain incompletely understood but are thought to be present during all stages of the disease, as well as in the prodromal, interictal and residual phases. On the other hand, observations on the effects of NMDA antagonists, such as ketamine and phencyclidine, reveal that hypoglutamatergic neurotransmission causes not only positive and negative but also cognitive schizophrenic symptoms. This review aims to summarize the different hypotheses about the origin of psychoses and to identify the optimal neuroimaging method that can serve to unite them in an integral etiological framework. We systematically searched Google scholar (with no concern to the date published) to identify studies investigating the etiology of schizophrenia, with a focus on impaired central neurotransmission. The complex interaction between the dopamine and glutamate neurotransmitter systems provides the long-needed etiological concept, which combines the neurodegenerative hypothesis with the hypothesis of impaired neurodevelopment in schizophrenia. Pharmaco-magnetic resonance imaging is a neuroimaging method that can provide a translation of scientific knowledge about the neural networks and the disruptions in and between different brain regions, into clinically applicable and effective therapeutic results in the management of severe psychotic disorders.

Retinoids Delivery Systems in Cancer: Liposomal Fenretinide for Neuroectodermal-Derived Tumors

Retinoids are a class of natural and synthetic compounds derived from vitamin A. They are involved in several biological processes like embryogenesis, reproduction, vision, growth, inflammation, differentiation, proliferation, and apoptosis. In light of their important functions, retinoids have been widely investigated for their therapeutic applications. Thus far, their use for the treatment of several types of cancer and skin disorders has been reported. However, these therapeutic agents present several limitations for their widespread clinical translatability, i.e., poor solubility and chemical instability in water, sensitivity to light, heat, and oxygen, and low bioavailability. These characteristics result in internalization into target cells and tissues only at low concentration and, consequently, at an unsatisfactory therapeutic dose. Furthermore, the administration of retinoids causes severe side-effects. Thus, in order to improve their pharmacological properties and circulating half-life, while minimizing their off-target uptake, various retinoids delivery systems have been recently developed. This review intends to provide examples of retinoids-loaded nano-delivery systems for cancer treatment. In particular, the use and the therapeutic results obtained by using fenretinide-loaded liposomes against neuroectodermal-derived tumors, such as melanoma, in adults, and neuroblastoma, the most common extra-cranial solid tumor of childhood, will be discussed.

Salvarsan for anthrax

Zikeev (BP. Gaz., 1924, No. 6) and Polyakov (ibid.) Report excellent therapeutic results

Hydrogen Sulfide in Skin Diseases: A Novel Mediator and Therapeutic Target

Together with nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H2S) is now recognized as a vital gaseous transmitter. The ubiquitous distributions of H2S-producing enzymes and potent chemical reactivities of H2S in biological systems make H2S unique in its ability to regulate cellular and organ functions in both health and disease. Acting as an antioxidant, H2S can combat oxidative species such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) and protect the skin from oxidative stress. The aberrant metabolism of H2S is involved in the pathogenesis of several skin diseases, such as vascular disorders, psoriasis, ulcers, pigment disorders, and melanoma. Furthermore, H2S donors and some H2S hybrids have been evaluated in many experimental models of human disease and have shown promising therapeutic results. In this review, we discuss recent advances in understanding H2S and its antioxidant effects on skin pathology, the roles of altered H2S metabolism in skin disorders, and the potential value of H2S as a therapeutic intervention in skin diseases.

Evaluation of Therapeutic Results of A Series of Moroccan Patients Aged 20 To 60 Years Treated According To The Acute Myeloid Leukaemia 03 Protocol At The Paediatric Haematology Oncology Centre In Casablanca

Acute Myeloblastic Leukaemia (AML) is a malignant haemopathy characterized by infiltration and accumulation in the bone marrow by myeloblastic-type blast cells causing medullary insufficiency. At the global level, the search for improved AML treatment is a long-standing concern.PurposeTo evaluate a new protocol AML MA 2003 its therapeutic results and tolerance in de novo AML patients.MethodsIt was a prospective and descriptive unicentre study carried out from January 2003 to December 2010. It included adults of 20 to 60 years with a diagnosis of de novo AML except a promyelocytic leukemia and without treatment by hydroxyurea.ResultsA total of 962 AMLs were diagnosed, 438 met the inclusion criteria, 48.4% women and 51.6% men with a median age of 39.8 years. 36.1% received hydroxyurea in pre-induction. 96.3% patients were induced, 76 (18%) died. A total of 178 (40.6%) of the 438 evaluable patients reached the maintenance phase. The overall survival of all patients was 32.4% at 5 years. Survival without event was 17.6% for all patients.ConclusionThe results of this single-center study illustrate the difficulty of treating AML patients despite the use of drugs recognised for their effectiveness in appropriate doses.