To the 125th anniversary of the first defense in Russia by a woman of a dissertation for the degree of Doctor of Medicine

Speaking about the lesser preparation of women for mental work, we do not want to express by this a hint of their inability for this work. On the contrary, we may be more than anyone else, would like to see it, would like full scope for female development and are sure that under the changed circumstances, the female mind will eventually become as receptive and productive as the male brain. If now more was opened up for a woman, or even any kind of application of mental forces in civil life, for example, if she could be a doctor, teacher, etc., then it goes without saying that along with the request, and these forces. V. M. Florinsky (1866)

A Broadening of Prospects: Female Progression in Austen and Eliot

<p>Austen and Eliot register the turbulence and transformation of their respective historic moments in the portrayal of a young heroine on the cusp of adulthood with a number of potential paths ahead of her. The heroines, like their societies, are caught between old and new as they seek to acknowledge the ties that bind them to the past and simultaneously create a future of their own. This dilemma reveals the nineteenth-century novel’s concerns of the individual’s ability to grow while being enmeshed in a network of relationships, and the place of the past in an increasingly unstable future. Beginning with Emma (1815) and The Mill on the Floss (1860), and concluding with a comparison of Persuasion (1817) and Middlemarch (1871), this thesis tracks Austen and Eliot’s depiction of female development which moves from a focus on the centrality of the childhood home, and in particular the heroine’s relationship with her father, to a narrative which ends on a more conscious note of ambiguity and broadening prospects. Emma and Mill both depict heroines who find their future in their past. Emma and Maggie develop and assert their own agency, but their circumstances and experiences of childhood bind them to their site of origin. Conversely, both Austen and Eliot’s later works enact a deliberate loosening of the hold the heroine’s childhood has on her, and Anne and Dorothea end up in very different places to where they began. They both reject their position as part of the rural landed gentry to instead gain entry into a more dynamic and inclusive community. This personal transition is accompanied by a more explicit delineation of the evolving socio-political landscape, an increase in the heroine’s mobility and fluidity, and an ending that frustrates a sense of stable closure in preference for one of more open possibility. Thus, so far from being read simply as ‘marriage plots’ Austen and Eliot subversively depict the young woman’s changing position and prospects as a matter of national importance.</p>

A Broadening of Prospects: Female Progression in Austen and Eliot

<p>Austen and Eliot register the turbulence and transformation of their respective historic moments in the portrayal of a young heroine on the cusp of adulthood with a number of potential paths ahead of her. The heroines, like their societies, are caught between old and new as they seek to acknowledge the ties that bind them to the past and simultaneously create a future of their own. This dilemma reveals the nineteenth-century novel’s concerns of the individual’s ability to grow while being enmeshed in a network of relationships, and the place of the past in an increasingly unstable future. Beginning with Emma (1815) and The Mill on the Floss (1860), and concluding with a comparison of Persuasion (1817) and Middlemarch (1871), this thesis tracks Austen and Eliot’s depiction of female development which moves from a focus on the centrality of the childhood home, and in particular the heroine’s relationship with her father, to a narrative which ends on a more conscious note of ambiguity and broadening prospects. Emma and Mill both depict heroines who find their future in their past. Emma and Maggie develop and assert their own agency, but their circumstances and experiences of childhood bind them to their site of origin. Conversely, both Austen and Eliot’s later works enact a deliberate loosening of the hold the heroine’s childhood has on her, and Anne and Dorothea end up in very different places to where they began. They both reject their position as part of the rural landed gentry to instead gain entry into a more dynamic and inclusive community. This personal transition is accompanied by a more explicit delineation of the evolving socio-political landscape, an increase in the heroine’s mobility and fluidity, and an ending that frustrates a sense of stable closure in preference for one of more open possibility. Thus, so far from being read simply as ‘marriage plots’ Austen and Eliot subversively depict the young woman’s changing position and prospects as a matter of national importance.</p>

Conditional knockdown of transformer in sheep blow fly suggests a role in repression of dosage compensation and potential for population suppression

The transformer (tra) gene is essential for female development in many insect species, including the Australian sheep blow fly, Lucilia cuprina. Sex-specific tra RNA splicing is controlled by Sex lethal (Sxl) in Drosophila melanogaster but is auto-regulated in L. cuprina. Sxl also represses X chromosome dosage compensation in female D. melanogaster. We have developed conditional Lctra RNAi knockdown strains using the tet-off system. Four strains did not produce females on diet without tetracycline and could potentially be used for genetic control of L. cuprina. In one strain, which showed both maternal and zygotic tTA expression, most XX transformed males died at the pupal stage. RNAseq and qRT-PCR analyses of mid-stage pupae showed increased expression of X-linked genes in XX individuals. These results suggest that Lctra promotes somatic sexual differentiation and inhibits X chromosome dosage compensation in female L. cuprina. However, XX flies homozygous for a loss-of-function Lctra knockin mutation were fully transformed and showed high pupal eclosion. Two of five X-linked genes examined showed a significant increase in mRNA levels in XX males. The stronger phenotype in the RNAi knockdown strain could indicate that maternal Lctra expression may be essential for initiation of dosage compensation suppression in female embryos.

Identification of four populations of Meloidogyne incognita in Georgia, USA capable of parasitizing tomato bearing Mi-1.2 gene

Meloidogyne incognita, the southern root-knot nematode (RKN), is the most predominant plant-parasitic nematode species of tomato and causes significant yield loss. The Mi-1.2 gene confers resistance in tomatoes to M. incognita; however, virulent RKN populations capable of parasitizing resistant tomato cultivars have been reported from different regions in the world. Four naturally occurring virulent populations of M. incognita were found in vegetable fields from four counties in Georgia with no history of tomato cultivation of the Mi gene. Two consecutive greenhouse trials showed that all four virulent RKN populations reproduced on tomato cultivars, including Amelia, Skyway, and Myrtle with the Mi-1 gene, while an avirulent population of M. incognita race 3 was unable to overcome host resistance. Virulent RKN populations varied in reproduction among resistant cultivars, with Ma6 population having the greatest reproduction potential. No difference in penetration potential of the virulent (Ma6) and avirulent populations were found on susceptible and resistant tomato cultivars. However, virulent Ma6 population females were successful at egg-laying, while the avirulent female development was arrested in the resistant cultivars. The virulent Ma6 population also induced feeding sites in the roots of resistant cultivars, while the avirulent population did not. To our knowledge, this is the first report of resistance-breaking populations of M. incognita in Georgia and the second state in the United States after California.

Regulation of sexually dimorphic abdominal courtship behaviors in Drosophila by the Tlx/tailless-like nuclear receptor, Dissatisfaction

Sexually dimorphic courtship behaviors in Drosophila melanogaster develop from the activity of the sexual differentiation genes, doublesex (dsx) and fruitless (fru), functioning with other regulatory factors that have received little attention. The dissatisfaction gene (dsf) encodes an orphan nuclear receptor homologous to vertebrate Tlx and Drosophila tailless that is critical for the development of several aspects of female- and male-specific sexual behaviors. Here, we report the pattern of dsf expression in the central nervous system and show that the activity of sexually dimorphic abdominal interneurons that co-express dsf and dsx is necessary and sufficient for vaginal plate opening in virgin females and abdominal curling in males during courtship. We find that dsf activity results in different neuroanatomical outcomes in females and males, promoting and suppressing, respectively, female development and function of the DDAG neurons depending upon the sexual state of dsx expression. We posit that dsf and dsx interact to specify sex differences in the neural circuitry for dimorphic abdominal behaviors.

Two transcriptionally distinct pathways drive female development in a reptile with both genetic and temperature dependent sex determination

How temperature determines sex remains unknown. A recent hypothesis proposes that conserved cellular mechanisms (calcium and redox; ‘CaRe’ status) sense temperature and identify genes and regulatory pathways likely to be involved in driving sexual development. We take advantage of the unique sex determining system of the model organism, Pogona vitticeps, to assess predictions of this hypothesis. P. vitticeps has ZZ male: ZW female sex chromosomes whose influence can be overridden in genetic males by high temperatures, causing male-to-female sex reversal. We compare a developmental transcriptome series of ZWf females and temperature sex reversed ZZf females. We demonstrate that early developmental cascades differ dramatically between genetically driven and thermally driven females, later converging to produce a common outcome (ovaries). We show that genes proposed as regulators of thermosensitive sex determination play a role in temperature sex reversal. Our study greatly advances the search for the mechanisms by which temperature determines sex.

Menopause as a stage of female development: psychoanalytic perspective

The object of this research is the psychoanalytic concepts of female development. The subject of this research is the phenomenon of the climacteric period in female development. The article analyzes and summarizes the psychoanalytic ideas on the development of women during menopause. 1. Climacteric period &ndash; the crisis period (G. Bibring); 2. Menopause as a trauma, narcissistic insult, backward development of libido, regression (H. Deutsch) 3. Menopause as a narcissistic rage (R. Lax); 4. Same as in puberty period, body is the focus of attention during menopause; climacteric period as part of femininity and emotions (D. Pines); 5. Menopause as a punishment (M. Klein). The author also include the examples from personal research practice. The novelty of this work consists in the summary of psychoanalytic ideas on the female development during climacteric period; as well as in elucidation of the phenomenon of menopausal complex. The menopausal complex implies: 1. Menopause as a traumatic event, accompanied by the emotions of narcissistic rage; aggression as a protection mechanism, resemblance of the aging process and its irreversibility; 2. Regression and re-actualization of castration emotions and narcissistic wounds, experience of inferiority and inability to control your body; 3. Experiencing the loss and mourning over the reproductive abilities and femininity; 4. Reaching menopause is likely in same age as mother; 5. Menopausal complex is accompanied by the fear of aging (or future), fear of being left and loneliness.