This chapter presents information about the methods that combine physical and mental workload/fatigue during ergonomic evaluation. The methods were identified through a systematic literature review. The search criteria were done through a literature search in databases like SciFinder, SciELO, ScienceDirect, etc. As result, the following methods are described: Global Load Scale, Multivariate Workload Assessment, Subjective Fatigue Symptoms Test, Fatigue Assessment Scale, Scale of Recovery for Exhaustion of Occupational Fatigue, Scale of Estimated Fatigue-Energy Points, Swedish Occupational Fatigue Inventory, NASA-TLX, Combined Cognitive and Physical Assessment, Laboratory Method of Economics and Sociology of Work, OWL Method, Ergonomic Checklist Method, RENAULT Method, Joyce Method, NERPA Method, ARBAN Method, and MAPFRE Method. As a conclusion, it is possible to affirm that there are some evaluation methods that provide better elements for an accurate evaluation, and others lack basic elements, which causes an incomplete/not accurate evaluation.