The extraction of maximum power is a big challenge in solar photovoltaic-based power plants due to varying atmospheric and meteorological parameters. The concept of array reconfiguration is applied for the maximum power extraction in solar PV plants. Using this approach, the occurrence of multiple peaks in P-V and I-V characteristics during partial shade can be smoothened and reduced significantly. Partial shading due to the movement of the cloud is considered in the research. The cloud movement mainly because of velocity and wind direction is used for creating various shading conditions. The main focus is to reduce the power losses during partial shading using a nature-inspired optimization approach to reconfigure the array for different types of shading conditions. A grey wolf optimizer-based bridge-linked total cross-tied (GWO-BLTCT) configuration is proposed in this paper. The performance of the proposed topology is compared with standard and hybrid topologies, namely, series-parallel, total cross-tied, BLTCT, and SuDoKu-BLTCT, based on performance indicators such as fill factor, performance ratio, power enhancement, and power loss. The proposed GWO-BLTCT outperforms the remaining topologies due to the least power loss and high fill factor. It also has the highest average power enhancement and performance ratio with 23.75% and 70.02% respectively.