Endothelial Cell Distribution After Flow Exposure With Two Stent Struts Placed in Different Angles

Stent implantation has been a primary treatment for stenosis and other intravascular diseases. However, the struts expansion procedure might cause endothelium lesion and the structure of the struts could disturb the blood flow environment near the wall of the blood vessel. These changes could damage the vascular innermost endothelial cell (EC) layer and pose risks of restenosis and post-deployment thrombosis. This research aims to investigate the effect of flow alterations on EC distribution in the presence of gap between two struts within the parallel flow chamber. To study how the gap presence impacts EC migration and the endothelialization effect on the surface of the struts, two struts were placed with specific orientations and positions on the EC layer in the flow chamber. After a 24-h exposure under wall shear stress (WSS), we observed the EC distribution conditons especially in the gap area. We also conducted computational fluid dynamics (CFD) simulations to calculate the WSS distribution. High EC-concentration areas on the bottom plate corresponded to the high WSS by the presence of gap between the two struts. To find the relation between the WSS and EC distributions on the fluorescence images, WSS condition by CFD simulation could be helpful for the EC distribution. The endothelialization rate, represented by EC density, on the downstream sides of both struts was higher than that on the upstream sides. These observations were made in the flow recirculation at the gap area between two struts. On two side surfaces between the gaps, meaning the downstream at the first and the upstream at the second struts, EC density differences on the downstream surfaces of the first strut were higher than on the upstream surfaces of the second strut. Finally, EC density varied along the struts when the struts were placed at tilted angles. These results indicate that, by the presence of gap between the struts, ECs distribution could be predicted in both perpendicular and tiled positions. And tiled placement affect ECs distribution on the strut side surfaces.

Non-Invasive in Vivo Quantification of Directional Dependent Variation in Mechanical Properties for Human Skin

Skin is the body’s largest organ, and it shows non-linear and anisotropic behavior under the deformation. This behavior of the skin is due to the waviness and preferred orientation (in a particular direction) of collagen fibers. This preferred orientation of collagen fibers results in natural pre-tension and anisotropy of the skin. The knowledge of natural skin pre-tension and anisotropy is essential during incisions and surgery. The available suction-based devices quantify the anisotropy through the displacement field and cannot measure the stress-strain relation in particular directions. Therefore, in the current study, an in vivo full-field measurement suction apparatus was developed to measure the stress and strain of skin in all planar directions through a single experiment. First, this apparatus was tested on silicone substrates of known properties, and then it was used to test the skin of 12 human forearms. Further, to check the effect of hand stability on the measurements, the obtained results of the skin were compared with the results of a standard test performed in the same skin using a steady setup. The consistency between these two results confirms that the stability of the hand does not influence the measurements of skin properties. Furthermore, using the developed apparatus, the skin’s anisotropy and its relation with the Kraissl’s lines orientation was quantified by measuring the toe and linear moduli at an interval of one degree. The minimum and maximum values of the toe and linear moduli were 0.52 ± 0.09 and 0.59 ± 0.11 MPa, and 3.09 ± 0.47 and 5.52 ± 1.13 MPa, respectively. Also, the direction of maximum moduli was found almost similar to Kraissl’s lines’ orientation. These results confirm the contribution of skin pre-tension on the anisotropy of the skin. The present apparatus mimics the tissue expansion procedure, where observation of the test may be helpful in the selection of size and shape of the expander.

Discrete (G'/G )-expansion: a Method Used to Get Exact Solution of Fdde (Fractional Differential-difference Equation) Linked With Nltl (Non-linear Transmission Line)

Here, we have used the discrete (G'/G)-expansion procedure with the derivative operator MR-L (modified Riemann-Liouville) and FCT (fractional complex transform) to find the exact/analytical solution of an electrical transmission line which is non-linear. Results include solutions for integer and fractional DDE. We consider two special cases of solutions: hyperbolic and trigonometric. Hyperbolic solutions indicate propagation of singular wave on the transmission line. Trigonometric solutions show propagation of complex wave.

The retrieval of a surgical blade broken within the alveolar bone during minimally traumatic tooth extraction

Minimally traumatic tooth removal is the norm for removing teeth when a dental implant is planned at that site. The quantity of available bone is the primary requisite to place an implant. The initial use of a scalpel blade to widen the periodontal space followed by the use of luxators is one of the techniques that is being followed for atraumatic extraction. A case of accidental breakage of a number 11 scalpel blade while attempting tooth removal and the method adopted in removing this portion of the blade without further bone destruction is reported here. The authors have not found any previously published cases, reporting the breakage of a scalpel blade during the bone expansion procedure and its management.

Three-dimensional Maxwellian extended Newtonian gravity and flat limit

In the present work we find novel Newtonian gravity models in three space-time dimensions. We first present a Maxwellian version of the extended Newtonian gravity, which is obtained as the non-relativistic limit of a particular U(1)-enlargement of an enhanced Maxwell Chern-Simons gravity. We show that the extended Newtonian gravity appears as a particular sub-case. Then, the introduction of a cosmological constant to the Maxwellian extended Newtonian theory is also explored. To this purpose, we consider the non-relativistic limit of an enlarged symmetry. An alternative method to obtain our results is presented by applying the semigroup expansion method to the enhanced Nappi-Witten algebra. The advantages of considering the Lie algebra expansion procedure is also discussed.

Structural Performance Analysis of a Novel Pyramidal Cellular Core Obtained through a Mechanical Expansion Process

Stiff and strong yet lightweight cellular structures have become widely designed and used as cores for the construction of sandwich panels to reach high stiffness and strength to weight ratios. A low-density pyramidal cellular core has been proposed for investigation in this work. The novel core is manufactured from stainless steel sheet type 304 through a mechanical expansion procedure which is described in detail. The out-of-plane stiffness and strength performance is estimated by an analytical model which is successfully validated through experimental tests. A comparative study with other existing cellular core configurations made from other materials indicates an average performance behavior for the investigated structure. However, potential for a further structural performance increase is observed and discussed

Experimental measurement of the specific mass of drilling fluids at high pressure and high temperature

The knowledge of specific mass of drilling fluids are of great importance in defining the characteristics of them during drilling wells. In the present work, the specific mass of distilled water was carried out in a PVT (Pressure-Volume-Temperature) cell using the Constant Composition Expansion procedure under high pressure and high temperature. Results showed a good agreement with literature valures.