Performance Evaluation of Selected Encryption Algorithms

Data security is a key aspect of today’s communication trend and growth. Various mechanisms have been developed to achieve this security. One is cryptography, which represents a most effective method of enhancing security and confidentiality of data. In this work, a hybrid based 136bit key algorithm involving a sequential combination of XOR (Exclusive –Or) encryption and AES (Advanced Encryption Standard) algorithm to enhance the security strength is developed. The hybrid algorithm performance is matched with XOR encryption and AES algorithm using encryption and decryption time, throughput of encryption, space complexity and CPU process time.

Comparative Study on the Effect of Two Different Sequential Combination Training Methods on Fat Reduction

In this paper, overweight or obese young women with sports experience and body fat rate > 30% were divided into groups to compare the effect of "HIIT" and "aerobic" exercise in different sequence combination training methods, and analyze whether "HIIT + Aerobic" is more effective than "aerobic + HIIT". The aim is to provide more effective training programs and establish scientific fitness awareness for overweight or obese young women who have sports experience.

Epigenetic activation of the elongator complex sensitizes gallbladder cancer to gemcitabine therapy

Background Gallbladder cancer (GBC) is known for its high malignancy and multidrug resistance. Previously, we uncovered that impaired integrity and stability of the elongator complex leads to GBC chemotherapy resistance, but whether its restoration can be an efficient therapeutic strategy for GBC remains unknown. Methods RT-qPCR, MS-qPCR and ChIP-qPCR were used to evaluate the direct association between ELP5 transcription and DNA methylation in tumour and non-tumour tissues of GBC. EMSA, chromatin accessibility assays, and luciferase assays were utilized to analysis the DNA methylation in interfering PAX5-DNA interactions. The functional experiments in vitro and in vivo were performed to investigate the effects of DNA demethylating agent decitabine (DAC) on the transcription activation of elongator complex and the enhanced sensitivity of gemcitabine in GBC cells. Tissue microarray contains GBC tumour tissues was used to evaluate the association between the expression of ELP5, DNMT3A and PAX5. Results We demonstrated that transcriptional repression of ELP5 in GBC was highly correlated with hypermethylation of the promoter. Mechanistically, epigenetic analysis revealed that DNA methyltransferase DNMT3A-catalysed hypermethylation blocked transcription factor PAX5 activation of ELP5 by disrupting PAX5-DNA interaction, resulting in repressed ELP5 transcription. Pharmacologically, the DNA demethylating agent DAC eliminated the hypermethylated CpG dinucleotides in the ELP5 promoter and then facilitated PAX5 binding and reactivated ELP5 transcription, leading to the enhanced function of the elongator complex. To target this mechanism, we employed a sequential combination therapy of DAC and gemcitabine to sensitize GBC cells to gemcitabine-therapy through epigenetic activation of the elongator complex. Conclusions Our findings suggest that ELP5 expression in GBC is controlled by DNA methylation-sensitive induction of PAX5. The sequential combination therapy of DAC and gemcitabine could be an efficient therapeutic strategy to overcome chemotherapy resistance in GBC.

EFFICACY OF MIFEPRISTONE FOLLOWED BY MISOPROSTOL VERSUSMISOPROSTOL ALONE IN MEDICAL MANAGEMENT OF EARLY PREGNANCY FAILURE

Purpose of the study- To study the efcacy of mifepristone followed by misoprostol over misoprostol alone in early pregnancy failure in terms of complete evacuation of uterus. METHODS: In a randomized comparative study at the Department of Obstetrics and Gynaecology of Kasturba Hospital, 100 women with early pregnancy failure and gestational age ≤12 weeks between January 2017 and December 2017 were recruited. Of these, 50 women were given a single oral dose of mifepristone (200 mg) followed by 800 mcg misoprostol vaginally (if required) after 24 hours and the other 50 women were treated with 800 mcg misoprostol vaginally alone. RESULTS: Complete evacuation of uterus was achieved in 96% women treated with a sequential combination of mifepristone and misoprostol versus 84% women treated with misoprostol alone. The difference in the rate of complete expulsion was 12% (p <0.05, 95% CI). Also, pre-treatment with mifepristone resulted in statistically signicant reduction in induction to abortion interval (2.40 ± 1.774 vs 3.30 ± 1.951 hr), amount of bleeding (402.2 ± 111.84 vs 535.0 ± 114.84 ml) and duration of bleeding (10.7 ± 2.30 vs 12.4 ± 3.38 days). CONCLUSION Medical treatment of early pregnancy failure with a sequential combination of mifepristone and misoprostol was more effective than misoprostol alone. Hence, women with early pregnancy failure may be offered mifepristone pretreatment before misoprostol to increase the chance of successful management, while reducing the need for surgery.

Quelle(s) stratégie(s) adopter pour sélectionner des cas dans une recherche qualitative ? Illustration à partir d’une recherche comparative sur les changements dans la structure du pouvoir exécutif en Equateur

What strategies should be adopted to select cases in a qualitative research ? Illustration from a comparative study on the changes in the structure of the executive branch in Ecuador. In a qualitative research design – particularly a comparative one - case selection is undoubtedly one of the most critical issues. The literature proposes a series of individual selection strategies, but in practice, researchers use them in combination. This discrepancy between theory and practice motivated us to propose a sequential combination of qualitative techniques for case selection that meet four objectives: to achieve variation in outcome, to respect the diversity of the set, to highlight the different degrees of a continuum, and to highlight the substantial importance of each case. The process was carried out in two stages: first, a pre-selection made directly by the researcher, and second the selection itself, carried out with the participation of experts by means of the Delphi method. The empirical basis of the proposal is the design of a comparative research on changes in the structure of executive power in Ecuador during the three presidential terms of Rafael Correa Delgado (2007–2009, 2009–2013, 2013–2017).

Structural changes of the tendon in experimental tendinopathy and administration of autologous platelet-rich plasma

Objectives assessment of structural changes in the calcaneal tendon tissue in experimental tendinopathy under autologous platelet-rich plasma. Material and methods. Twenty mature Wistar rats, selected for the study, were divided into 5 groups. Rats of all groups received intra- and peritendinous injections of 0.5 ml of 10% sterile talc suspension to provide the experimental modeling of tendinopathy of the calcaneal tendon. Then the tendinopathy area was treated by injections of autologous platelet-rich plasma (PRP), a hyaluronic acid preparation "Rusvisk" (Rusvisk, Russia) and their sequential combination. The results were evaluated after 10 weeks in the autopsy preparations using a light microscopy method and morphometry. Results. The histological signs characteristic of tendinopathy were revealed, such as the disorganization of collagen structures, mucoid and lipoid degeneration, neovascularization, lymphoid and histiocytic infiltration. The injection of PRP, hyaluronic acid, or their sequential combination in the area of simulated tendinopathy led to changes in the histological presentation of the tissue. As a result, the collagen matrix had less signs of disorganization and less pronounced degenerative changes, as well as manifestations of the inflammatory process in the peritenon and the soft tissues surrounding the tendon, in comparison with the histological profile, which was observed in micropreparations in animals with tendinopathy who had no treatment. Conclusion. The introduction of PRP into the area of the calcaneal tendon has reduced the manifestations of the inflammatory process, disorganization of the collagen matrix, promoted the enhancement of collagen synthesis by cells and, ultimately, the processes of tissue remodeling.

Sequential Effects of Indirect, Direct, and Virtual Sport Experiences on Consumer Learning

The purpose of this study is to expand the theoretical knowledge of consumer learning by testing both the single and sequential effects of indirect, direct, and virtual sport experiences on sport brand knowledge, attitudes, and choice behavior in two laboratory experiments. Experiment I shows that virtual experience is as effective as direct experience in consumer learning. In Experiment II, designed to explore the impact of sequential combinations of sport experiences on consumer learning, the sequential combination of direct and virtual experiences results in greater brand knowledge than the combination of indirect and direct experiences. Exposure to direct experience proceeding with virtual experience is more effective at influencing brand attitudes than the combination of indirect and direct experiences. Th e results indicate that sport consumers are more likely to select sport brands at choice contexts when exposed to virtual experience in combination with direct experience.