Evaluation the efficacy in healing from cutaneous leishmaniasis by intraregional injection of metronidazole solution with acetylsalicylic acid topically (pads)

The cross sectional study was determined the efficaciousness of healing from oriental sore by intraregional injection of metronidazole with applying acetylsalicylic acid pads. The study was performed on 85 patients in age between 2-18 years (forty males and forty five females) in Tikrit city from March 2016 until August 2018, The cure rate was 77.64%. The study showed the marked improvement the lesions. Scaring was minimal or absent following healing of treated lesions. The only side effect of treatment result localized pain and sometime reaction at web site of injection. The study showed that the highest cure rate at age 6-10 years was 85% and at the age of 11 - 18 years the cure rate was 80% and at the age of 2-5 years, the cure rate was 66.6%. This study was recorded the analysis of the healing from lesion in cutaneous leishmaniasis following administration of intraregional injection of metronidazole solution with applying acetylsalicylic acid pads is significant. The aim of the current study has evaluated the efficaciousness of intraregional metronidazole injection with acetylsalicylic acid locally for healing of lesion from oriental sore. http://dx.doi.org/10.25130/tjps.24.2019.082

Quality Evaluation of Ayurvedic Crude DrugDaruharidra, Its Allied Species, and Commercial Samples from Herbal Drug Markets of India

Berberis aristataknown as “Daruharidra” in Ayurveda is a versatile medicinal plant used singly or in combination with other medicinal plants for treating a variety of ailments like jaundice, enlargement of spleen, leprosy, rheumatism, fever, morning/evening sickness, snakebite, and so forth. A major bioactive marker of this genus is an alkaloid berberine, which is known for its activity against cholera, acute diarrhea, amoebiasis, and latent malaria and for the treatment of oriental sore caused byLeishmania tropica. Although the roots ofB. aristataare considered as the official drug (Ayurvedic Pharmacopoeia of India), the study revealed that different species ofBerberis,namely.B. asiatica,B. chitria,andB. lyciumare also used under the name ofDaruharidrain different parts of the country. Detailed physicochemical and phytochemical studies of subjects like total ash, acid insoluble ash, tannins, and total alkaloids were calculated from the shade dried powdered material according to the recommended procedures. Further, heavy metal studies and quantitative estimation of berberine through HPTLC have also been performed as per ICH guidelines. A detailed study of fourBerberisspecies, namelyB. aristata,B. asiatica,B. chitria,andB. lycium,which are implicated asDaruharidraand collected from wild and ten commercial samples procured from various important drug markets in India has been carried out, which may be useful to pharmaceutical industries for the authentication of the commercial samples and exploring the possibilities of using other species as a substitute ofB. aristata.