Survivorship and functional outcome of a cemented acetabular component with bulk roof autograft for severe acetabular dysplasia: 12- to 23-year follow-up

Aims: Primary aim was to determine survival of a cemented acetabular component with bulk roof autograft with a minimum of 12 years follow-up. The secondary aim was to determine the clinical outcome. Methods: A cohort of 62 consecutive patients (74 hips) undergoing cemented total hip arthroplasty with acetabular bulk roof autograft for acetabular dysplasia were retrospectively identified. The group consisted of 57 female patients (67 hips) and 5 male patients (7 hips) with a mean age at operation of 45 years. No patient was lost to follow-up, however 9 patients died had during the study period. The Oxford Hip Score (OHS), Forgotten Joint Score (FJS), EuroQol 5-Dimensional Score (EQ-5D), Short Form (SF-12) physical score and patient satisfaction were used to assess clinical outcome for patients with a surviving prosthesis. Results: The median follow-up was 16.6 (13.4–19.1) years. 6 revisions were performed during the follow-up period, all of which were due to aseptic loosening of the acetabular component. The all-cause Kaplan Meier survival rate for the acetabular component was 99% at 10 years, 95% at 15 years and 83% at 20 years. Neither age, gender, femoral osteotomy or polyethylene (UHMW vs. cross-linked) were significant predictors of aseptic revision of the acetabular component. There were no case of graft resorption and all grafts were radiologically incorporated. 45 patients were available for functional assessment at a mean follow-up of 18.2 years. The mean OHS was 37.8, FJS was 55.7, EQ5D was 0.73, and SF-12 physical component was 43.2. No patient was dissatisfied, with 2 patients reporting a neutral satisfaction, 7 stating they were satisfied and the remaining 36 were very satisfied. Conclusions: A cemented acetabular component with bulk roof autograft for dysplasia offers excellent survival with good to excellent functional outcome with high patient satisfaction in the medium- to long-term.

Direct Transfer to Angiosuite Triage Strategy for Patients Undergoing Mechanical Thrombectomy in a Rural Setting

BACKGROUND A direct admission to angiosuite (DAA) strategy in transfer patients with large vessel occlusion (LVO) is considered to decrease stroke time metrics and benefit functional outcomes. However, feasibility and effectiveness of DAA have not been established in rural settings. Fast door‐to‐reperfusion times and high‐quality reperfusion are key predictors of outcome in patients with LVO. To reduce treatment times in transferred patients with suspected LVO, we initiated a DAA triage protocol in 2017. METHODS We conducted a nested interventional cohort study of adult patients with anterior LVO from January 2015 to August 2019 transferred to our center from an outside hospital. Patients were divided into DAA for mechanical thrombectomy (MT) and patients directly admitted to the emergency department (DAED). DAED was subdivided into patients undergoing MT and patients who did not. Workflow times and clinical and radiographic outcomes were analyzed. RESULTS Forty‐five DAA patients and 241 DAED patients (DAED patients undergoing MT=134 patients and DAED patients not undergoing MT=107 patients) were identified. DAA patients had significantly shorter median door‐to‐arterial‐puncture times (15 versus 71 minutes) and puncture‐to‐recanalization times (27 versus 42.5 minutes). At discharge, DAA patients had a significant decrease in median admission National Institutes of Health Stroke Scale (NIHSS) score (ΔNIHSS score 10 versus 4; P =0.02), and higher rate of dramatic clinical improvement (ΔNIHSS score >10; 48.9% versus 23.5%; P <0.001). Both groups had comparable rates of functional independence (modified Rankin Scale; mRS 0–2; 36.1% versus 29.2%; P =0.52), and mortality at 90 days ( P =0.63). When mortality was excluded, DAA patients showed a significant proportion of excellent functional outcome (mRS 0–1; 50% versus 26%) before ( P =0.04) and after ( P =0.02) adjusting for confounders. CONCLUSIONS DAA is feasible and can safely reduce reperfusion times in transferred patients with LVO to MT centers in a rural setting. Reducing workflow times may impact the functional recovery of patients undergoing MT.

Global white matter structural integrity mediates the effect of age on ischemic stroke outcomes

Background The relationship of global white matter microstructural integrity and ischemic stroke outcomes is not well understood. Aims To investigate the relationship of global white matter microstructural integrity with clinical variables and functional outcomes after acute ischemic stroke. Methods A retrospective analysis of neuroimaging data from 300 acute ischemic stroke patients with magnetic resonance imaging brain obtained within 48 hours of stroke onset and long-term functional outcomes (modified Rankin, mRS) was performed. Peak width of skeletonized mean diffusivity (PSMD), as a measure of global white matter microstructural injury, was calculated in the hemisphere contralateral to the acute infarct. Multivariable linear and logistic regression analyses were performed to identify variables associated with PSMD and excellent functional outcome (mRS < 2) at 90 days, respectively. Mediation analysis was then pursued to characterize how PSMD mediates the effect of age on acute ischemic stroke functional outcomes. Results White matter hyperintensity volume, age, pre-stroke disability, and normal-appearing white matter mean diffusivity were independently associated with increased PSMD. In logistic regression analysis, increased infarct volume and PSMD were independent predictors of excellent functional outcome. Additionally, the effect of age on functional outcomes was indirectly mediated by PSMD ( P < 0.001). Conclusions As a marker of global white matter microstructural injury, increased PSMD mediates the effect of increased age to contribute to poor acute ischemic stroke functional outcomes. PSMD could serve as a putative radiographic marker of brain age for stroke outcomes prognostication.

Functional Outcome of Closed Metacarpal Fractures Treated with Mini Fragment Plates and Screws

Aim: To assess the functional outcome after metacarpal fracture fixation with mini fragment plates. Study design: Prospective cohort study Place and duration of study: Department of Orthopaedic Surgery, GTTH, Lahore from 01-01-2015 to 31-07-2020. Methodology: Sixteen patients who were operated with mini fragment plates for metacarpal fractures. Functional outcome was evaluated with help of American Society for Surgery of the Hand (ASSH) Total Active Flexion (TAF) score and the disabilities of the arm, shoulder. Results: Union was achieved in all patients. The functional outcome was excellent in 13 and good in 2 and poor in 1. Three cases of infection (all superficial) were noted, which settled with dressings and antibiotics. Conclusion: Mini fragment plates for metacarpals fractures are a good option, providing early mobilization and excellent functional outcome. Keywords: Functional outcome, Metacarpal fracture, Mini fragment plat, Open reduction internal fixation (ORIF)

Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-II (TRACE II): rationale and design

Background and purposeTenecteplase (TNK) is a promising agent for treatment of acute ischaemic stroke (AIS). We hypothesised that recombinant human TNK tissue-type plasminogen activator (rhTNK-tPA) is non-inferior to rt-PA in achieving excellent functional outcome at 90 days, when administered within 4.5 hours of ischaemic stroke onset.Methods and designTenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events (TRACE) is a phase III, multicentre, prospective, randomised, open-label, blinded-end point non-inferiority study. Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg (single bolus) to a maximum of 25 mg or rt-PA 0.9 mg/kg (10% bolus+90% infusion/1 hour) to a maximum of 90 mg. Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomesThe primary study outcome is excellent functional outcome defined as modified Rankin Scale (mRS) 0–1 at 90 days. Secondary efficacy outcomes include favourable functional outcome defined as mRS ≤2 at 90 days, ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale. Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.DiscussionThere is no completed registration study of TNK in AIS worldwide. TRACE II strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China.Trial registration numberNCT04797013.

RADIOLOGICAL AND FUNCTIONAL OUTCOME OF DUAL PLATING IN DISTAL FEMUR MULTIFRAGMENTARY ARTICULAR FRACTURES: A SHORT TERM STUDY

Introduction: In this prospective cases series, we are reporting a mean 12-month follow up of the utilisation of dual plating technique for multi fragmentary articular distal femur fractures. Our technique consists of a lateral distal femoral locked plate and a low prole locked medial plate through a modied anterior (Swashbuckler) approach for the xation of C2, C3 fractures. Patients and Methods: 15 patients (9 males and 6 females) presented with supra condylar femoral fractures type C2/C3, according to Müller long bone classication and its revision, OA/OTA classication. These fractures were treated using dual plating through swashbuckler approach. They were followed up for clinical and radiological outcomes. Secondary outcomes included post-operative complications. Results: Mean time of radiological union in studied population was 18 weeks with a range of 14-24 weeks. We did not observe any post-operative varus angulation.12 out of 14 patients had good to excellent functional outcome. Fair outcome was reported in only two patients Conclusion: The technique of Dual plating xation using modied anterior approach (swashbuckler) for type C2,C3 distal femoral fractures is an efcient method of management. It has several advantages such as precise exposure, easy manipulation, anatomical reduction and stable xation. However, operative indications and principles should be strictly followed. The surgical technique must be perfect and the biomechanical qualities of the implants must be understood to prevent the development of major complications

FUNCTIONAL OUTCOME IN PERCUTANEOUS ELASTIC STABLE INTRAMEDULARY NAILING TECHNIQUE OF METACARPAL BONE FRACTURE

AIMS AND OBJECTIVES: The aim of this study was to evaluate functional outcome of metacarpal fractures managed by percutaneous elastic stable intramedullary nails along with its functional outcome. METHOD: The extra-articular metacarpal fracture were managed by inserting two pre-bent elastic stable nails in antegrade manner after making entry point (dorso-medialy and dorso-lateraly) through base of the metacarpal bone. The nails act as three point xation and provide stable xation. Early mobilisation is commenced for providing early healing and decrease postoperative decreased range of motion at metacarpophalangeal/interphalangeal joints and stiffness. Nails were removed 3 week after radiological sign of union. RESULTS: 32 extra-articular metacarpal fractures treated with percutaneous elastic stable nails were evaluated between 1 2 September 2018 to 31 August 2020. The functional outcome was assessed using disability arm shoulder and hand (DASH) score with mean score th 1 of 2 at 6 month follow-up and total active motion (TAM) score which was excellent in 81.2% of the patients (n=26), good in 9.4% of cases (n=3), fair in 9.4% of the cases (n=3).All fracture proceeded to bony union. CONCLUSIONS: It was concluded that indirect reduction and early xation with percutaneous elastic stable intramedullary nailing with 2 nails is very safe and effective treatment modality for extra-articular metacarpal fracture with excellent functional outcome.

Shaft of humerus fracture managed by anteromedial plating through anterolateral approach.

Objective: To assess the use of anteromedial plating in the shaft of humerus fractures concerning the union of fracture and to assess the frequency of complications associated with this approach. Study Design: Cross Sectional study. Setting: United Medical and Dental College, Shaheed Muhatarma Benazir Bhutto Medical College Lyari and Khairpur Medical College. Period: 15 January 2016 to 15 January 2019. Material & Methods: All the patients aged 18 years or over presenting with the shaft of humerus fracture were included in the study. The anterolateral approach was used to expose the fracture, and the plate was applied on the anteromedial surface of the humerus. Rodriguez Merchan criteria assessed the functional outcome. All the data was recorded on designated Performa and entered and analyzed by SPSS version 20. Results: Two hundred twenty-five patients of both sexes were included in the study. The mean age of the patients in the study was 38.06 ± 11.51. The mean union time of fracture in our study was 11.76 ± 2.72 weeks. Functional outcome was assessed using Rodriguez Merchan criteria excellent functional outcome was achieved in 165(73.3%) of the cases and good functional outcome in 58 (25.8%) of cases. A fair outcome was achieved in 2 (0.9%) cases. Conclusion: Anteromedial plating is the viable option for treating shaft of humerus fractures as it is associated with a high union rate and low or no complications.

Penetrating deep pelvic injury due to “less-lethal” beanbag munitions: a case report and policy implications

“Less-lethal” munitions are designed to cause incapacitation and are often used by law enforcement officers. Although these munitions are not designed to cause severe injury, recent reports have demonstrated that they can cause severe injury, permanent disability, and death. The long-term consequences of injury due to less-lethal munitions are not well understood. We present a case of osteomyelitis and pelvic abscess secondary to a retained beanbag munition following penetrating injury in the setting of a patient with delayed presentation for care. The patient underwent surgical removal of the retained beanbag munition and irrigation and debridement of the osteomyelitis and pelvic abscess with an excellent functional outcome. We discuss the public health and policy implications of serious injury due to less-lethal munitions.

FUNCTIONAL OUTCOME OF DISTAL HUMERUS FRACTURE BY PARATRICEPITAL TWO WINDOW APPROACH

Background-Most of distal humerus fractures are dealt with olecranon osteotomy approach which stand as cumbersome process resulting in excessive soft tissue damage and excess hardware interposition. Alternate paratricepital two window approach has been advocated by many authors as better approach to deal with AO type A, B, and C1 type distal humerus fractures. AIM -To evaluate functional outcome of distal humerus fracture xation through paratricepital two window approach Materials & Methods – A complete of 30 patients of closed fracture distal humerus fracture underwent open fracture xation through paratricepital approach. Average age of patient was 35yr .Regular follow up and physiotherapy sessions were carried out. Average period of follow up was 12 month. Results – Out of 30 patients 28 were nally followed up till 1 year, one patient died in between while another one undergoes implant removal due to infection. From 28, 20 patients has excellent functional outcome, 3 has good, 4 has fair outcome and one patient has poor results in terms of MEPS and DASH score. Conclusion – Based on present study and data analysis we conclude that distal humerus fracture treated through paratricepital two window approach results in excellent functional outcome which is evident from ability to early start various day to day to day activities like performing st nd personal hygiene, combing hairs ,putting shirt- shoes themselves and starts eating themselves by 1 or 2 week of surgery .Unlike traditional approach like Olecranon osteotomy , it maintains adequate Tricep extensor mechanism ,does minimal soft tissue damage ,minimal post op pain ,promote early wound healing and avoid excessive hardware transposition