Depression, Anxiety, and Suicide After Stroke: A Narrative Review of the Best Available Evidence

Depression and anxiety each affect around 1 in 3 people during the first year after a stroke. Suicide causes the death of about 3 to 4/1000 stroke survivors during the first 5 years. This narrative review describes the best available evidence for the epidemiology of depression, anxiety, and suicide; their prevention; and the treatment of anxiety and depression. We conclude with directions for future research.

Meta-Analysis of Emotional Regulation Training on Reducing the Symptoms of Depression Disorder

Aim: Emotional regulation is one of the areas that has been considered in the epidemiology of depression in the last decade. The results of studies on the effect of emotional regulation training on reducing the symptoms of depression disorder vary and contradictory. Therefore, the aim of this meta-analysis was to determine the effectiveness of emotional regulation training on reducing the symptoms of depression disorder. Methods: For this research, meta-analysis technique were utilized, in which the results of various research studies were integrated in order to determine the size of the effect of parental education programs. To achieve this purpose, the related literature concerning the topic was investigated in dissertations and research articles published in scientific journals from 2006 to 2020 were reviewed. Based on the research inclusion criterion, 17 research studies, including 14 articles and 3 dissertations were considered for meta-analysis. Data analysis and calculation of effect size were performed using the CMA2 software and the Hedges g-index. Findings: The findings from this meta-analysis showed that the random effect of emotional regulation training on reducing the symptoms of depression disorder (1/39) (P< 0/001), which is evaluated in accordance with the Cohen table of the large effect size. Conclusion: It seems that emotional regulation training can be used as a suitable method for reducing depression in educational and therapeutic centers.

Epidemiology of depression and factors associated with depression in cancer patients’ in Ethiopia: protocol for systematic review and meta-analysis

BackgroundThere is no pooled evidence regarding the prevalence and potential associated factors of depression among cancer patients in East Africa community. Hence, the current review aimed to examine the prevalence and associated factors of depression among cancer patients in East Africa.Method: A computerized systematic literature search was made in MEDLINE, Scopus, PubMed, Science Direct, and Google Scholar. Each database was searched from its start date to June 2020. All included articles were published in English, which evaluated prevalence and associated factors of depression among cancer patients in East Saharan Africa. Pooled estimations with 95% confidence interval (CI) were calculated with DerSimonian-Laird random-effects model. Publication bias was evaluated by using inspection of funnel plots and statistical tests.DiscussionSince we are using existing anonymized data, ethical approval is not required for this study. Our results can be used to guide clinical decisions about the most efficient way to prevent and treat depression among cancer patients.Systematic review registrationsubmitted to Prospero

The Osteopathic Approach to Treating Depression in Children and Adolescents

Evidence confirms that children and adolescents can experience the whole spectrum of mood disorders and suffer from the significant morbidity and mortality associated with them. Effective treatment often relies on physicians developing advanced communication skills with their patients. Enhanced communication will help decipher the etiology of the patient’s depression and, in addition to serotonin-regulating medications, will optimize treatment. Osteopathic medicine offers an effective treatment model through osteopathic manipulative treatment (OMT) because of the inseparability of physical and mental health. Osteopathic medicine takes a holistic view in which somatic, visceral and psychological dysfunction are united. Thus, physicians who incorporate OMT into their practice will help treat psychopathologies, such as depression and its accompanying somatic dysfunctions. This paper discusses the epidemiology of depression, the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) depression criteria, screening algorithms, current treatment protocols, osteopathic considerations to treating depression, and lastly, OMT and its role in treatment.

Epidemiology of depression in primary care: Findings from the Mental Health in Primary Care (MeHPriC) project, Lagos, Nigeria

Objective To estimate the rate and correlates of depression in primary care using data from the Mental Health in Primary Care (MeHPriC) project, Lagos, Nigeria. Methods Adult attendees (n=44,238) of 57 primary care facilities were evaluated for depression using the Patient Health Questionnaire (PHQ-9). Apart from the socio-demographic details, information was also collected regarding the use of alcohol and other psychoactive substances, presence of chronic medical problems, level of functionality, and perceived social support. Anthropometrics measures (weight and height) and blood pressure were also recorded. Results A total of 27,212 (61.5%) of the participants were females. There were 32,037 (72.4%) participants in the age group 25-60 years. The rate of major depression (PHQ-9 score 10 and above) was 15.0% (95% CI 14.6–15.3). The variables independently associated with depression include age 18–24 years (OR 1.69), female sex (OR 2.39), poor social support (OR 1.14), having at least one metabolic syndrome component (OR 1.57), significant alcohol use (OR 1.13) and functional disability (OR 1.38). Conclusion Our study showed that the rate of depression in primary care in Nigeria is high. Screening for all primary care attendees for depression will be an important step towards scaling up mental health services in Nigeria and other developing countries.

Vitamin D and Depression in Women: A Mini-review

: Affective-related disorders, including depression, are constantly rising, complicating people's personal lifestyle increasing disqualification and hospital care. Because of the high intensity of urbanization, our lifestyle and food have altered dramatically in the last twenty years. These food modifications have been associated with scores of depression and other affective-related disorders in urbanized countries with high economic levels. Nutrients imbalance is considered as one of the critical causes enabling the pathophysiological mechanisms for the development of psychiatric disorders. The application of additional nutritional interventions for treatment of mood deteriorations can be beneficial for both the prophylaxis and therapy of affective-related disorders. This paper will review recent research on the relation of Vitamin D levels and the epidemiology of depression in women. : In this paper, we will provide an overview of the results of a variety of different studies taking into account research which both suggests and refutes an association. Based on these findings we will propose important directions for future research in relation to this topic.

Epidemiology of Depression and Anxiety in Gout: A Systematic Review and Metaanalysis

Objective.To conduct a systematic review of depression and anxiety among patients with gout that specifically evaluates the prevalence, incidence, determinants, and effects of these mental health comorbidities.Methods.We conducted a literature search in Medline, Embase, Cochrane Database of Systematic Reviews, CINAHL, and PsycINFO using indexed terms and key words to identify studies reporting on depression/anxiety in patients with gout. This review included full-text articles published in English that reported on patients with gout, evaluated depression/anxiety using a routinely reported measure, and provided estimates or sufficient data on the prevalence, incidence, determinants, or effects of depression/anxiety. Metaanalyses were conducted using random effects models.Results.Twenty of 901 articles identified through the search strategy met our inclusion criteria. All 20 studies evaluated depression, while only 10 assessed anxiety (50%). Metaanalyses suggest a positive association between mental health disorders and gout, as resultant pooled OR were 1.29 (95% CI 1.07–1.56) for depression and 1.29 (95% CI 0.96–1.73) for anxiety. Findings from four studies reporting on the incidence of depression in patients with gout resulted in a pooled HR of 1.17 (95% CI 1.01–1.36). Significant determinants of depression included number of tophi, frequency of flares, and oligo/polyarticular gout.Conclusion.Our systematic review suggests that depression and anxiety are significantly associated with gout, highlighting the need for future research to focus on the onset of mental disorders after gout diagnosis. We also identify potential targets for intervention.

Genetic epidemiology of depression in the molecular era

Familial aggregation of major depressive disorder has been well established, but identification of specific genetic markers underlying this condition has been challenging. The aims of this chapter are to: (1) provide an overview of the results of twin, family, and adoption studies, which have demonstrated that both genetic and environmental factors contribute to the aetiology of depression; (2) discuss studies of depression in the molecular genetics era, including linkage, association, genome-wide association, sequencing, polygenic, and pharmacogenetic studies; and (3) review challenges in identifying genetic factors underlying depression. The next phase of research in the genetic epidemiology of depression will require integration of research on genetic and environmental risk factors and increased recognition of the role of biologic and genetic vulnerability factors for depression.