Abstract. This paper describes GCAM-USA v5.3_water_dispatch, an open source model that represents key interactions across economic, energy, water, and land systems in a consistent global framework, with subnational detail in the United States. GCAM-USA divides the world into 31 geopolitical regions outside the United States (U.S.) and represents the U.S. economic and energy systems in 51 state-level regions (50 states plus the District of Columbia). The model also includes 235 water basins and 384 land-use regions; 23 of each fall at least partially within the United States. GCAM-USA offers a level of process and temporal resolution rare for models of its class and scope, including detailed subnational representation of U.S. water demands and supplies and sub-annual operations (day/night for each month) in the U.S. electric power sector. GCAM-USA can be used to explore how changes in socioeconomic drivers, technological progress, or policy impact demands for, and production of, energy, water, and crops at a subnational level in the United States, while maintaining consistency with broader national and international conditions. This paper describes GCAM-USA’s structure, inputs, and outputs, with emphasis on new model features. Four illustrative scenarios encompassing varying socioeconomic and energy system futures are used to explore subnational changes in energy, water, and land-use outcomes. We conclude with information about how public users can access the model.