Palladium-Catalyzed Cross-Coupling of 4-Tosyloxyquinazolines with H-phosphonates and Phosphine Oxides: An Efficient Access to 2-(hetero)aryl-4-phosphorylated Quinazolines

A series of 2-(hetero)aryl-4-phosphonylated quinazolines have been successfully synthesized via the palladium-catalyzed C-O/P-H cross-coupling reaction of 4-tosyloxyquinazoline with H-phosphonate and phosphine oxides in moderate to excellent yields. This efficient and green methodology provided alternative straightforward protocol for the introduction of phosphorus groups to quinazoline compounds at C4 position via C-O activation and enriched the quinazoline structure libraries.

Cellulose to Electricity Conversion by Bias-Free Biofuel Cell

The conversion of biomass and other cellulose-based materials to clean energy has high promise for a sustainable world. Herein we present a green methodology to convert cellulose directly into electrical...

Recent Developments on Synthesis of Indole Derivatives Through Green Approaches and Their Pharmaceutical Applications

Indole moiety is often found in different classes of pharmaceutically active molecules having various biological activities including anticancer, anti-viral, anti-psychotic, antihypertensive, anti-migraine, anti-arthritis and analgesic activities. Due to enormous applications of indole derivatives in pharmaceutical chemistry, a number of conventional synthetic methods as well as green methodology have been developed for their synthesis. Green methodology has many advantages including high yields, short reaction time, and inexpensive reagents, highly efficient and environmentally benign over conventional methods. Currently, the researchers in academia as well as in pharmaceutical industries have been developing various methods for the chemical synthesis of indole based compounds via green approaches to overcome the drawbacks of conventional methods. This review reflects the last ten years developments of the various greener methods for the synthesis of indole derivatives by using microwave, ionic liquids, water, ultrasound, nanocatalyst, green catalyst, multicomponent reaction and solvent-free reactions etc. (please see the scheme below). Furthermore, the applications of green chemistry towards developments of indole containing pharmaceuticals and their biological studies have been represented in this review.