Detekcija IgG protutijela na Rickettsia typhi

Background. Rickettsia typhi belongs to the typhus group of rickettsiae and causes endemic typhus. Cases of endemic typhus and seropositivity to R. typhi have been reported in the neighbouring China and Russia. However, little is known of the endemic typhus in Kazakhstan. The purpose of this study was to evaluate the prevalence of IgG antibodies to R. typhi in the population of southern region of Kazakhstan. Methods. A total of 253 individuals (142 women, 111 men) aged from 1 to 71 years were recruited into the study. Detection of serum IgG antibodies against R. typhi was performed by enzyme-linked immunosorbent assay (ELISA). Results. The overall R. typhi seropositivity has reached 34.4%. The highest seroprevalence of 91.8% was recorded in the Turkestan Region. The lowest seropositivity of 6.1% was detected in the village Lepsinsk, Almaty Region. The seroprevalence did not differ significantly between genders. Seropositivity in adult individuals was not significantly associated with age, but positive results were not detected in the age group of children under 14 years. Conclusion. The obtained results confirm active circulation of R. typhi in the Turkestan and Almaty Regions of Kazakhstan. The data indicate an urgent need for further studies aimed to evaluate the clinical impact caused by R. typhi in the southern region of Kazakhstan.

Case Report of Scrub Typhus

Scrub typhus is an acute, febrile, infectious illness that is caused by Orientia tsutsugamushi. Scrub and murine endemic typhus infections are under-diagnosed causes of febrile illness across the tropics, and it is not known how common they are in Bangladesh. Here reporting a case who presented with high grade fever for 7 days associated with headache, abdominal discomfort, cough and receiving inj ceftriaxone for 2 days considering as a case of enteric fever. Forty-eight hours after admission, the presence of continued high grade fever, conjunctival congestion, headache, loose motion, cough, low platelet, elevated transaminase raised the possibility of a different aetiology. The two most likely differentials being dengue and malaria. Finally, typhus was discovered due to history of field visit, presence of eschar and raised titre of WF OXK antigen. All other causes of fever were ruled out by history, clinical examination and relevant investigations. Patient was treated with capsule doxycycline and other supportive therapy and become afebrile within 48 hours. This uncommon clinical scenario should be taken into account in the management of patients with high fever on admission.J Bangladesh Coll Phys Surg 2018; 36(3): 123-127