Industry 4.0 radically alters manufacturing organization and management, fostering collection and analysis of increasing amounts of data. Advanced data analytics, such as machine learning (ML), are essential for implementing Industry 4.0 and obtaining insights regarding production, better decision support, and enhanced manufacturing quality and sustainability. ML outperforms traditional approaches in many cases, but its complexity leads to unclear bases for decisions. Thus, acceptance of ML and, concomitantly, Industry 4.0, is hindered due to increasing requirements of fairness, accountability, and transparency, especially in sensitive-use cases. ML does not augment organizational knowledge, which is highly desired by manufacturing experts. Causal discovery promises a solution by providing insights on causal relationships that go beyond traditional ML’s statistical dependency. Causal discovery has a theoretical background and been successfully applied in medicine, genetics, and ecology. However, in manufacturing, only experimental and scattered applications are known; no comprehensive overview about how causal discovery can be applied in manufacturing is available. This paper investigates the state and development of research on causal discovery in manufacturing by focusing on motivations for application, common application scenarios and approaches, impacts, and implementation challenges. Based on the structured literature review, four core areas are identified, and a research agenda is proposed.