Prioritizing high-contact occupations raises effectiveness of vaccination campaigns

A twenty-year-old idea from network science is that vaccination campaigns would be more effective if high-contact individuals were preferentially targeted. Implementation is impeded by the ethical and practical problem of differentiating vaccine access based on a personal characteristic that is hard-to-measure and private. Here, we propose the use of occupational category as a proxy for connectedness in a contact network. Using survey data on occupation-specific contact frequencies, we calibrate a model of disease propagation in populations undergoing varying vaccination campaigns. We find that vaccination campaigns that prioritize high-contact occupational groups achieve similar infection levels with half the number of vaccines, while also reducing and delaying peaks. The paper thus identifies a concrete, operational strategy for dramatically improving vaccination efficiency in ongoing pandemics.

Improvement of Fermi-Level Pinning and Contact Resistivity in Ti/Ge Contact Using Carbon Implantation

Effects of carbon implantation (C-imp) on the contact characteristics of Ti/Ge contact were investigated. The C-imp into Ti/Ge system was developed to reduce severe Fermi-level pinning (FLP) and to improve the thermal stability of Ti/Ge contact. The current density (J)-voltage (V) characteristics showed that the rectifying behavior of Ti/Ge contact into an Ohmic-like behavior with C-imp. The lowering of Schottky barrier height (SBH) indicated that the C-imp could mitigate FLP. In addition, it allows a lower specific contact resistivity (ρc) at the rapid thermal annealing (RTA) temperatures in a range of 450–600 °C. A secondary ion mass spectrometry (SIMS) showed that C-imp facilitates the dopant segregation at the interface. In addition, transmission electron microscopy (TEM) and electron energy loss spectroscopy (EELS) mapping showed that after RTA at 600 °C, C-imp enhances the diffusion of Ge atoms into Ti layer at the interface of Ti/Ge. Thus, carbon implantation into Ge substrate can effectively reduce FLP and improve contact characteristics.

Методики исследования электрического контактного сопротивления в структуре металлическая пленка--полупроводник

The electrical contact resistance significantly affects the efficiency of thermoelements. In the case of high doped thermoelectric materials, the tunneling mechanism of conductivity prevails at metal-semiconductor interface, which makes it possible to obtain a contact resistance of less than 10-8 Ohm•m2. Low resistance values significantly complicate its experimental determination. Work present three techniques and a measuring stand for the investigation of contact resistance. The techniques are based on the measurement of the total electrical resistance, which consists of transient contact resistance and the resistance of the thermoelectric material with its subsequent exclusion. The developed techniques differ in the arrangement of the investigated contacts on the samples, in the methods of measurement and processing of the obtained results, and make it possible to determine the specific contact resistance of the order of 10-10 Ohm•m2.

Sex-Specific Brain Responses to Imaginary Dance but Not Physical Dance: An Electroencephalography Study of Functional Connectivity and Electrical Brain Activity

To date, most neurophysiological dance research has been conducted exclusively with female participants in observational studies (i.e., participants observe or imagine a dance choreography). In this regard, the sex-specific acute neurophysiological effect of physically executed dance can be considered a widely unexplored field of research. This study examines the acute impact of a modern jazz dance choreography on brain activity and functional connectivity using electroencephalography (EEG). In a within-subject design, 11 female and 11 male participants were examined under four test conditions: physically dancing the choreography with and without music and imagining the choreography with and without music. Prior to the EEG measurements, the participants acquired the choreography over 3 weeks with one session per week. Subsequently, the participants conducted all four test conditions in a randomized order on a single day, with the EEG measurements taken before and after each condition. Differences between the male and female participants were established in brain activity and functional connectivity analyses under the condition of imagined dance without music. No statistical differences between sexes were found in the other three conditions (physically executed dance with and without music as well as imagined dance with music). Physically dancing and music seem to have sex-independent effects on the human brain. However, thinking of dance without music seems to be rather sex-specific. The results point to a promising approach to decipher sex-specific differences in the use of dance or music. This approach could further be used to achieve a more group-specific or even more individualized and situationally adapted use of dance interventions, e.g., in the context of sports, physical education, or therapy. The extent to which the identified differences are due to culturally specific attitudes in the sex-specific contact with dance and music needs to be clarified in future research.

Age-specific Contribution of Contacts to Transmission of SARS-CoV-2 in Germany

Introduction: Current estimates of pandemic spread using infectious disease models in Germany for SARS-CoV-2 often do not use age-specific infection parameters and are not always based on known contact matrices of the population. They also do not usually include setting-based information of reported cases and do not account for age-specific underdetection of reported cases. Here, we report likely pandemic spread using an age-structured model to understand the age- and setting-specific contribution of contacts to transmission during all phases of the COVID-19 pandemic in Germany. Methods: We developed a deterministic SEIRS model using a pre-pandemic contact matrix. The model is optimized to fit reported age-specific SARS-CoV-2 incidences from the Robert Koch Institute, includes information on setting-specific reported cases in schools and integrates age and pandemic period-specific parameters for underdetection of reported cases deduced from a large population-based seroprevalence study. Results: We showed that taking underreporting into account, younger adults and teenagers are the main contributors to infections during the first three pandemic waves in Germany. Overall, the contribution of contacts in schools to the total cases in the population was below 10% during the third wave. Discussion: Accounting for the pandemic phase and age-specific underreporting seems important to correctly identify those parts of the population where quarantine, testing, vaccination, and contact-reduction measures are likely to be most effective and efficient. In the future, we will aim to compare current model estimates with currently emerging during-pandemic age-specific contact survey data.

Lockdown impact on age-specific contact patterns and behaviours, France, April 2020

Background Many countries implemented national lockdowns to contain the rapid spread of SARS-CoV-2 and avoid overburdening healthcare capacity. Aim We aimed to quantify how the French lockdown impacted population mixing, contact patterns and behaviours. Methods We conducted an online survey using convenience sampling and collected information from participants aged 18 years and older between 10 April and 28 April 2020. Result Among the 42,036 survey participants, 72% normally worked outside their home, and of these, 68% changed to telework during lockdown and 17% reported being unemployed during lockdown. A decrease in public transport use was reported from 37% to 2%. Participants reported increased frequency of hand washing and changes in greeting behaviour. Wearing masks in public was generally limited. A total of 138,934 contacts were reported, with an average of 3.3 contacts per individual per day; 1.7 in the participants aged 65 years and older compared with 3.6 for younger age groups. This represented a 70% reduction compared with previous surveys, consistent with SARS-CoV2 transmission reduction measured during the lockdown. For those who maintained a professional activity outside home, the frequency of contacts at work dropped by 79%. Conclusion The lockdown affected the population's behaviour, work, risk perception and contact patterns. The frequency and heterogeneity of contacts, both of which are critical factors in determining how viruses spread, were affected. Such surveys are essential to evaluate the impact of lockdowns more accurately and anticipate epidemic dynamics in these conditions.

Using Multilevel Regression with Poststratification for Estimating Subnational Age-Specific Contact Patterns

The spread and transmission dynamics of directly transmitted airborne pathogens, such as SARS-CoV-2, are fundamentally determined by in-person contact patterns. Reliable quantitative estimates of contact patterns are critical to modeling and reducing the spread of directly transmitted infectious diseases. While national-level contact data are available in many countries, including the United States, local-level estimates of age-specific contact patterns are key since disease dynamics and public health policy vary by geography. However, collecting contact data for each state would require a very large sample and be prohibitively expensive. To overcome this challenge, we develop a flexible model to estimate age-specific contact patterns at the subnational level using national-level interpersonal contact data. Our model is based on dynamic multilevel regression with poststratification. We apply this approach to a national sample of interpersonal contact data collected by the Berkeley Interpersonal Contact Study (BICS). Results illustrate important state-level variation in levels and trends of contacts across the US.

Improved Electrical Characteristics of 1200V/20A 4H-SiC Diode by Substrate Thinning and Laser Annealing

In this paper, two kinds of silicon carbide (SiC) backside metallization processes were developed, which were backside thinning combined with laser annealing to form ohmic contact and direct rapid annealing (RTA) to form ohmic contact. The specific contact resistivity obtained by both annealing processes was 3.4E-5 Ω·cm2 to 3.8E-5 Ω·cm2. In order to obtain the effect of thinning combined with laser annealing process on forward conduction characteristics of medium voltage devices,1200V/20A JBS diode was developed, and the backside contact adopted the above two annealing schemes, the thickness of 4H-SiC substrate is 200μm. According to the statistical results of hundreds of JBS diodes, the electrical characteristics of the two types JBS are basically the same. Compared with the JBS diode without substrate thinning, the forward conduction voltage (VF) of the thinned JBS diode is decreased about 0.048V. When the substrate of 1200V SiC JBS diodes is reduced to 80μm, the value of VF can only be reduced by about 0.0868V.

Cell–cell contact landscapes in Xenopus gastrula tissues

Molecular and structural facets of cell–cell adhesion have been extensively studied in monolayered epithelia. Here, we perform a comprehensive analysis of cell–cell contacts in a series of multilayered tissues in the Xenopus gastrula model. We show that intercellular contact distances range from 10 to 1,000 nm. The contact width frequencies define tissue-specific contact spectra, and knockdown of adhesion factors modifies these spectra. This allows us to reconstruct the emergence of contact types from complex interactions of the factors. We find that the membrane proteoglycan Syndecan-4 plays a dominant role in all contacts, including narrow C-cadherin–mediated junctions. Glypican-4, hyaluronic acid, paraxial protocadherin, and fibronectin also control contact widths, and unexpectedly, C-cadherin functions in wide contacts. Using lanthanum staining, we identified three morphologically distinct forms of glycocalyx in contacts of the Xenopus gastrula, which are linked to the adhesion factors examined and mediate cell–cell attachment. Our study delineates a systematic approach to examine the varied contributions of adhesion factors individually or in combinations to nondiscrete and seemingly amorphous intercellular contacts.