Analysis of Factors Affecting Druging Compliance in Lung Tuberculosis Patients: Theory of Health Belief Model (HBM) in the Working Area of the Health Center, Dompu City

Tuberculosis is an infectious disease caused by TB bacteria called Mycobacterium tuberculosis, which mostly attacks the lungs (80%), but can also attack other organs such as bones, lymph glands, joints, lining of the brain, intestines, kidneys. , genitals, and others. The purpose of this study in general was to determine the effect of the Health Belief Model theory on medication adherence to tuberculosis patients. This research is a quantitative study with the method of observation and cross sectional approach. The research sample was 119 tuberculosis sufferers. The independent variables are perceived vulnerability, severity, barriers, cues for action, perceived benefits and self-efficacy. Adherence to taking medication in tuberculosis patients as the dependent variable. The results showed that simultaneously there was an effect of variable X on Y with a significance value of 0.000 and a large effect of 10.2%. And simultaneously it shows that there is an influence of variables X and Y with a significance value of 0.000 and a large influence of 12.8%. Data analysis using path analysis. Simultaneously there is an effect of the application of the Health Belief Model theory on adherence to taking medication in tuberculosis patients.

Synchronous Neck Melanoma and Papillary Thyroid Cancer: A Case Report

Introduction: The synchronous malignant melanoma of the neck and papillary thyroid cancer is rare but severe condition. Here, we describe the case of a patient with papillary thyroid cancer and melanoma invasivum cutis. Case report: A 49-year-old man had a change on the neck at the last 3-4 months that he accidentally noticed. He had hoarse voice, was afebrile, did not sweat more than usual and feel exhausted, without rash or itching. MR examination of the neck and upper mediastinum before the surgery indicated a hyperintense focal change in the left thyroid gland which dimensions was 19 x 15 mm and several hyperintense inhomogeneous lymph glands of the jugular chain, on the both sides, with different sizes. On the basis of the conducted analyzes, in addition to total thyroidectomy, two-sided functional dissection of the lymph nodes of the neck was performed. The pathohistological diagnosis of the left lobus was: Carcinoma papillary glandulae thyreoideae invasivum (G-I, nG-I, pT2, Lx, Vo). CT of head, neck and thorax were made, where it was noticed that the CT of the head and lungs were normal. PET/CT findings indicated that there was no rest or recurrence of the tumor. Conclusion: The message from this case report is that when diagnosing and treating thyroid cancer, the observed changes in the neck lymph nodes also indicate cancers of non-thyroid pathology such as malignant melanoma.

Stihl's disease in an adult

In 1897, the English pediatrician Still described a peculiar disease characterized by multiple swelling of the joints due to damage to the periarticular soft parts, swelling of the lymph glands, enlargement of the spleen and chronic course.

On the X-ray technique of malignant tumors Brock (S’trahlentherapie. Bd. 13, № 1)

Analyzing this technique Brock (S'trahlentherapie. Bd. 13, No. 1) strongly points out the need for the corresponding lymph glands to be protected from the action of x-rays during the X-ray examination of malignant tumors.

To the question of the classification of the inguinal lymph glands and the sources of their blood supply

The inguinal lymphatic gland, the largest in the human body, was one of the first to which the attention of anatomists was drawn in ancient times.

New ways of specific therapy for tuberculosis of skin and mucous membranes. Wісhmаnn (Arch. f. Dermal, u. Syph., 1922, Bd. 139)

Proceeding from the assumption that the lymph glands of our body serve as a place of production and accumulation of specific antibodies at tuberculosis infection, the author suggests using for therapeutic purposes injections of extracts or glands from the same patient or extracted from another. He considers the most suitable glands in the stage of swelling and edema; he cautions against using extracts from softening and lumpy glands.

To the surgical treatment of uterine cancer

As you know, the largest% of women who die after surgery for uterine cancer die from sepsis, and the pathogens of the latter are microbes that have entered the pelvic tissue and lymph glands even before the operation.

The Roles of the LIM Domain Proteins in Drosophila Cardiac and Hematopoietic Morphogenesis

Drosophila melanogaster has been used as a model organism for study on development and pathophysiology of the heart. LIM domain proteins act as adaptors or scaffolds to promote the assembly of multimeric protein complexes. We found a total of 75 proteins encoded by 36 genes have LIM domain in Drosophila melanogaster by the tools of SMART, FLY-FISH, and FlyExpress, and around 41.7% proteins with LIM domain locate in lymph glands, muscles system, and circulatory system. Furthermore, we summarized functions of different LIM domain proteins in the development and physiology of fly heart and hematopoietic systems. It would be attractive to determine whether it exists a probable “LIM code” for the cycle of different cell fates in cardiac and hematopoietic tissues. Next, we aspired to propose a new research direction that the LIM domain proteins may play an important role in fly cardiac and hematopoietic morphogenesis.

Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila

The hematopoietic system of Drosophila is a powerful genetic model for studying hematopoiesis, and vesicle trafficking is important for signal transduction during various developmental processes; however, its interaction with hematopoiesis is currently largely unknown. In this article, we selected three endosome markers, Rab5, Rab7, and Rab11, that play a key role in membrane trafficking and determined whether they participate in hematopoiesis. Inhibiting Rab5 or Rab11 in hemocytes or the cortical zone (CZ) significantly induced cell overproliferation and lamellocyte formation in circulating hemocytes and lymph glands and disrupted blood cell progenitor maintenance. Lamellocyte formation involves the JNK, Toll, and Ras/EGFR signaling pathways. Notably, lamellocyte formation was also associated with JNK-dependent autophagy. In conclusion, we identified Rab5 and Rab11 as novel regulators of hematopoiesis, and our results advance the understanding of the mechanisms underlying the maintenance of hematopoietic homeostasis as well as the pathology of blood disorders such as leukemia.