Association Between Baseline Buccal Telomere Length and Progression of Kidney Function: The Health and Retirement Study

We aimed to evaluate associations of baseline telomere length with overall and annual change in estimated glomerular filtration rate (eGFR) and trajectory of kidney function during an 8-year follow-up. A total of 3,964 participants of the Health and Retirement Study (HRS) were included. We identified three trajectory groups of kidney function: consistently normal (n=1,163 or 29.3%), normal to impaired (n=2,306 or 58.2%), and consistently impaired groups (n=495 or 12.5%). After controlling for age, sex, race, education, smoking, drinking, diabetes, heart disease, blood pressure, body mass index, total cholesterol, and hemoglobin A1c, participants with longer telomere length were 20% less likely (odds ratio [OR]=0.80, 95% confidence interval [CI]: 0.69-0.93, P=0.003) to have a normal to impaired kidney function trajectory than a consistently normal function trajectory. Telomere length was not associated with changing rate of eGFR over 8 years (P=0.45). Participants with longer telomere length were more likely to have consistently normal kidney function.

Selection of Optimum Nonlinear Confusion Component of Information Confidentiality Mechanism Using Grey Theory Based Decision-Making Technique

In this age of internet communication, the security of digital information is one of the main issues. The privacy of data depends upon the encryption using some secure algorithm. The selection of robust cryptosystems to ensure confidentiality is a major concern to decrease the risk of cryptographic attacks. In this article, we have implemented a grey theory-based decision-making technique for the election of a robust cryptosystem that complies with all the cryptographic parameters. Six different already proposed encryption algorithms are selected as the alternatives of the decision-making problem and the parameters concerned for the decision are entropy, correlation coefficient, the number of pixels changing rate (NPCR), unified average changing intensity (UACI). The algorithm ranked as first by using grey-based decision-making method can be utilized for secure data encryption.

Evaluation of Early Prognostic Factors in Patients With Pancreatic Ductal Adenocarcinoma Receiving Gemcitabine Together With Nab-paclitaxel

Background: Gemcitabine together with nab-paclitaxel (GnP) has been shown to improve outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). However, the predictive markers for treatment effects remain unclear. This study aimed to identify early prognostic factors in patients with PDAC receiving GnP. Patients and Methods: We analyzed 113 patients who received GnP for PDAC and evaluated the relationship between clinical factors and outcomes. Results: The median survival time (MST) was 1.2 years. In multivariate analysis, baseline carbohydrate antigen 19-9 (CA19-9) ≥747 U/ml [hazard ratio (HR)=1.9], baseline controlling nutrition status (CONUT) score ≥5 (HR=3.7) and changing rate of CA19-9 after two GnP cycles ≥0.69 (HR=3.7) were independent risk factors for poor prognosis. When examining outcomes according to pre-chemotherapeutic measurable factors (baseline CA19-9 and CONUT), the MSTs of patients with pre-chemotherapeutic zero risk factors (pre-low-risk group, n=63) and one or more risk factors (pre-high-risk group, n=50) were 1.7 and 0.65 years (p<0.001), respectively. The MST for those with a changing rate of CA19-9 after two GnP cycles <0.69 and ≥0.69 was significantly different in both groups (2.0 and 1.2 years in the pre-low-risk group, p<0.001; 1.0 and 0.52 years in the pre-high-risk group, p<0.001). Conclusion: These results may be useful for decision-making regarding treatment strategies in patients with PDAC receiving GnP.

Study on Self-Sensing Performance of Graphene-Modified FRP Bars

At present, the distributed long-gauge optical sensor on fiber reinforced polymer(FRP) bar cannot be manufactured through integrated production. On the other hand, the point-sensing technology of the self-sensing bar will cause deviations in structural health monitoring (SHM). To solve these issues, applying the graphene/epoxy on FRP members is a feasible method for the piezoresistive characteristics of graphene. In this paper, basalt FRP (BFRP) bars with graphene/epoxy film were tested under static tensile load and the resistance was measured at the same time until they were broken down. The results suggested that the changing rate of resistance was linearly correlated to the strain. This fact indicated that the graphene-modified BFRP bar can well reflect the stress condition of the structural member within a safe range.

Comparative Assessment and Future Prediction Using CMIP6 and CMIP5 for Annual Precipitation and Extreme Precipitation Simulation

This study assesses the improvement of the latest Coupled Model Intercomparison Project Phase 6 (CMIP6) over Coupled Model Intercomparison Project Phase 5 (CMIP5) for precipitation simulation. Precipitation simulations under different future climate scenarios are also compared in this work. The results show that: 1) CMIP6 has no overall advantage over CMIP5 in simulating total precipitation (PRCPTOT) and maximum consecutive dry days (CDD). The performance of CMIP6 increases or decreases regionally in PRCPTOT and consecutive dry days. But it is slightly worse than CMIP5 in simulating very wet days (R95pTOT). 2) Comparing the trend test results of CMIP5 and CMIP6 in the future, there are more areas with significant trend based on Mann–Kendall test in CMIP6 compared with that of CMIP5. The differences in PRCPTOT are mainly found in Amazon Basin and Western Africa. The differences between the R95pTOT trends mainly noticeable in South America and Western Africa, and the differences in CDD are mainly reflected in Central Asia, Sahara Desert and central South America. 3) In Southern South America and Western North America, the PRCPTOT changing rate of CMIP6 in the future under various scenarios is always greater than that of CMIP5; in Alaska, Western Africa, Southern Africa, the PRCPTOT changing rate of CMIP6 in the future under various scenarios is always less than that of CMIP5. In Southern South America, the R95pTOT changing rate of CMIP6 in the future under various scenarios is always greater than that of CMIP5; in Alaska, East Asia, North Asia, the R95pTOT changing rate of CMIP6 in the future under various scenarios is always less than that of CMIP5. In almost half of the regions, the CDD changing rate of CMIP6 is less than that of CMIP5 under all scenarios, namely Australia, Amazon Basin, Southern South America, Central America, Western North America, Central North America, Eastern North America, Central Asia, Tibet.

Compulsory Islanding Transition Strategy Based on Fuzzy Logic Control for a Renewable Microgrid System

Advantages of microgrid integrated with a renewable energy system have been acknowledged in more and more applications. Operating steadily during different modes is of great significance, and different modes transferring must be transient, seamless, and reliable to maintain the continuous electricity supply for loads, especially sensitive ones. As a semicontrolled switch that is unable to shut instantly until the zero point of its current, thyristors should be forced to be turned off by certain strategies to minimise the influence brought by the delay of modes transferring. In this paper, a compulsory turn-off strategy based on fuzzy logic control of converter output voltage is proposed. With the strategy, an alterable reverse voltage is applied across the conducting thyristor by dynamically adjusting the output voltage reference instruction and closed-loop control parameters depending on the changing rate rather than detecting the polarity of voltage or current. Constraints from acquisition of analog data and error of digital calculation will be eliminated. Finally, simulation and experimental results verify the effectiveness of the proposed strategy.

Efficacy of Increased Salt and Water Intake on Pediatric Vasovagal Syncope: A Meta-Analysis Based on Global Published Data

Objective: This study was designed to assess the efficacy of increased salt and water intake in the treatment of pediatric vasovagal syncope (VVS) based on a meta-analysis of global data.Methods: Following the established inclusion criteria, seven databases, Cochrane Library, EMBASE, PubMed, Web of Science, VIP, Wanfang, and China National Knowledge Infrastructure (CNKI), were searched using specific terms. The Cochrane Bias risk assessment tool was used as a quality assessment tool of the included studies, and publication bias was assessed by funnel plots. Review Manager 5.4 software was used to analyze the efficacy of the included studies, taking the negative changing rate of the head-up tilt test (HUTT) and recurrence rate of syncope or presyncope as therapeutic efficacy evaluations.Results: In total, 5 randomized controlled trials (RCTs) were finally obtained, using the negative changing rate of the HUTT as an efficacy evaluation, while in 4 of the studies, the recurrence rate of syncope or presyncope was also evaluated. A total of 233 children with VVS were included in the salt and water intervention group. The cases in the control group were treated with non-medicinal conventional therapy. The results revealed that the negative changing rate of the HUTT in the intervention group (144/233, 61.8%) was higher than that in the control group (48/179, 26.8%), and the difference was significant (P &lt; 0.00001). The recurrence rate of syncope or presyncope in the intervention group (85/195, 43.6%) was lower than that in the control group (86/144, 59.7%), and the difference was significant (P = 0.002).Conclusion: The current findings suggest that increased salt and water intake may increase the negative changing rates of the HUTT and reduce syncope or presyncope recurrence rates in pediatric patients with VVS.