Non-covalent modification of thrombolytic agent nattokinase: simultaneous improvement of fibrinolysis activity and enzymatic stability

Folic acid modified chitosan (CS-FA) was synthesized and applied to modify Nattokinase (NK), a thrombolytic agent, for better fibrinolysis activity and stability. It provides great opportunities in curing cardiovascular disease (CVD), a leading cause of death globally.

Integrated assessment haemostasis pregnant women with gestosis

The parameters of the kaolinaktivirovannoy thrombelastographic at physiological gestation, moderate, and severe gestosis. The significant differences between groups for the intensification of intravascular coagulation and fibrinolysis activity. Option and the severity of the changes thrombelastographic determine the need for correction hemocoagulation violations during gestation thrombohemorrhagic to prevent complications in pregnancy.

Integrated assessment haemostasis pregnant women with gestosis

The parameters of the kaolinaktivirovannoy thrombelastographic at physiological gestation, moderate, and severe gestosis. The significant differences between groups for the intensification of intravascular coagulation and fibrinolysis activity. Option and the severity of the changes thrombelastographic determine the need for correction hemocoagulation violations during gestation thrombohemorrhagic to prevent complications in pregnancy.

Comparison of Curative Effect of Cryosupernatant and Fresh Frozen Plasma at Complex Treatment of Disseminated Intravascular Coagulation Syndrome in Patients with Severe Concomitant Injury

Results of comparative study of cryoplasmic therapy applied at complex treatment of 168 patients with disseminated intravascular coagulation syndrome were presented. In 56 patients complex therapy included cryosupernatant plasma (CSNP) and 112 patients received fresh frozen plasma (FFP). Study of coagulation and fibrinolysis system showed that restoration of fibrinolysis activity, physiologic anticoagulants and normalization of plasma fibrinogen levels occurred sooner when CSNP was used. Application of CSNP promoted the relaxation of disease severity, prevention of thrombotic complications and decrease of lethality (by 14.2%) to a greater extent as compared to FFP use.