dynamical heterogeneity
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2021 ◽  
Author(s):  
Benjamin Partridge ◽  
Sara Gonzalez Anton ◽  
Reema Khorshed ◽  
George Adams ◽  
Constandina Pospori ◽  
...  

Multi-potent progenitor (MPP) cells act as a key intermediary step between haematopoietic stem cells and the entirety of the mature blood cell system. Their eventual fate determination is thought to be achieved through migration in and out of spatially distinct niches. Here we first analyze statistically MPP cell trajectory data obtained from a series of long time-course 3D in-vivo imaging experiments on irradiated mouse calvaria, and report that MPPs display transient super-diffusion with apparent non-Gaussian displacement distributions. Second, we explain these experimental findings using a run-and-tumble model of cell motion which incorporates the observed dynamical heterogeneity of the MPPs. Third, we use our model to extrapolate the dynamics to time-periods currently inaccessible experimentally, which enables us to quantitatively estimate the time and length scales at which super-diffusion transitions to Fickian diffusion. Our work sheds light on the potential importance of motility in early haematopoietic progenitor function.


2021 ◽  
pp. 1-9
Author(s):  
N.T.T. Ha ◽  
M.T. Lan ◽  
N.V. Hong ◽  
P.K. Hung

The structural transformation and dynamical heterogeneity in Germania (GeO2) are investigated via molecular dynamics (MD) simulation. The MD model with 5499 atoms was constructed under pressure up to 150 GPa and at a temperature of 3500 K. The structural transformation mechanism has been studied by observing domain structures and boundary oxygen atoms. The simulation result reveals that GeO2 consists of separate domains and boundaries in its melt structure. Under compression, the structure of GeO2 changes gradually and represents many types of structures. The melt structure exhibits many structural domains Dx, and polymorphism appears at pressures of 12 and 20 GPa. The change of tetrahedral structure to octahedral structure in germanium coordination occurred in parallel with the process of merging and splitting of domain structure. Moreover, the existence of high- and low-density phases in GeO2 melt is indicated. The high-density phase is D6 domain and boundary oxygen while the low-density phase is D4 and D5 domain. The compression mechanism in GeO2 melt mainly is a reduction of average Voronoi volume of oxygen and Voronoi volume of D6, boundary atoms oxygen. Furthermore, we find the dynamical heterogeneity at ambient pressure. The separate “fast” regions and “slow” regions in GeO2 are detected via link-cluster function.


2021 ◽  
Vol 2070 (1) ◽  
pp. 012064
Author(s):  
Mai Van Dung ◽  
Tran Thanh Dung ◽  
Truong Duc Quynh ◽  
Nguyen Manh Tuan ◽  
Nguyen Van Yen ◽  
...  

Abstract We have studied the structural and dynamical characteristics of xAl2O3(1-x)SiO2 system by means of molecular dynamics simulation at 3000 K using the Born-Mayer potentials. The structural properties have been analysed through the radial distribution function and structural factor. The simulation shows that our results are in good agreement with previous experimental and simulated data. The dynamical heterogeneity (DH) is investigated via the analysis of mobile, immobile, and random atoms. Our simulation indicates that the liquids exists dynamical heterogeneity.


2021 ◽  
Vol 31 (8) ◽  
pp. 083121
Author(s):  
K. L. Rossi ◽  
R. C. Budzinski ◽  
B. R. R. Boaretto ◽  
T. L. Prado ◽  
U. Feudel ◽  
...  

2021 ◽  
Vol 127 (4) ◽  
Author(s):  
Rahul N. Chacko ◽  
François P. Landes ◽  
Giulio Biroli ◽  
Olivier Dauchot ◽  
Andrea J. Liu ◽  
...  

2021 ◽  
Vol 154 (21) ◽  
pp. 215101
Author(s):  
Mantu Santra ◽  
Aniruddha Seal ◽  
Kankana Bhattacharjee ◽  
Suman Chakrabarty

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