hyperlipidemic rabbit
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KLF4 Upregulation in Atherosclerotic Thoracic Aortas: Exploring the Protective Effect of Colchicine-based Regimens in a Hyperlipidemic Rabbit Model

2021 ◽  
Author(s):  
Konstantinos S. Mylonas ◽  
Alkistis Kapelouzou ◽  
Michael Spartalis ◽  
Michael Mastrogeorgiou ◽  
Eletherios Spartalis ◽  
...  
Keyword(s):  
Protective Effect ◽  
Rabbit Model ◽  
Hyperlipidemic Rabbit

scholarly journals Hyperlipidemic Rabbit Models for Anti-Atherosclerotic Drug Development

2020 ◽  
Vol 10 (23) ◽  
pp. 8681
Author(s):  
Manabu Niimi ◽  
Yajie Chen ◽  
Haizhao Yan ◽  
Yao Wang ◽  
Tomonari Koike ◽  
...  
Keyword(s):  
Risk Factor ◽  
Drug Development ◽  
Apolipoprotein B ◽  
Molecular Mechanisms ◽  
Lipoprotein Metabolism ◽  
Mrna Editing ◽  
Experimental Animals ◽  
Transfer Protein ◽  
Hyperlipidemic Rabbit ◽  
Plasma Apolipoprotein

Hyperlipidemia or dyslipidemia is a major risk factor for atherosclerotic diseases. Experimental animals play an important role in elucidating the molecular mechanisms of the pathophysiology of hyperlipidemia as well as in drug development. Rabbits are one of the most suitable models to study human hyperlipidemia because many features of the lipoprotein metabolism of rabbits are similar to those of humans such as LDL-rich lipoproteins in plasma, apolipoprotein B mRNA editing, and cholesteryl ester transfer protein. Currently, three types of rabbit models are commonly used for studying hyperlipidemia: (1) diet-induced hyperlipidemic rabbits, (2) spontaneous hyperlipidemic rabbits, and (3) gene-manipulated rabbits (transgenic and knockout rabbits). In this review, we give an overview of the features of hyperlipidemic rabbits and discuss the usefulness of rabbits for the development of anti-atherogenic drugs.

scholarly journals Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Tingting Yuan ◽  
Yi Zhong ◽  
Yingge Wang ◽  
Ting Zhang ◽  
Rui Lu ◽  
...  
Keyword(s):  
Gene Editing ◽  
Hyperlipidemic Rabbit

Transplantation of genetically modified hepatocytes after liver preconditioning in Watanabe heritable hyperlipidemic rabbit

2018 ◽  
Vol 224 ◽  
pp. 23-32 ◽  
Author(s):  
Hadrien Tranchart ◽  
Martin Gaillard ◽  
Papa Saloum Diop ◽  
Sylvie Goulinet ◽  
Panagiotis Lainas ◽  
...  
Keyword(s):  
Genetically Modified ◽  
Hyperlipidemic Rabbit

scholarly journals EFFECTS OF RESVERATROL ON ATHEROSCLEROTIC LESIONS IN WATANABE HERITABLE HYPERLIPIDEMIC RABBIT

2018 ◽  
Vol 71 (11) ◽  
pp. A2100
Author(s):  
Takafumi Kurosawa ◽  
Yuxin Li ◽  
Takafumi Hiro ◽  
Atsushi Hirayama
Keyword(s):  
Atherosclerotic Lesions ◽  
Hyperlipidemic Rabbit

Overexpression of Toll-Like Receptors 2, 3, 4, and 8 Is Correlated to the Vascular Atherosclerotic Process in the Hyperlipidemic Rabbit Model: The Effect of Statin Treatment

2017 ◽  
Vol 54 (3) ◽  
pp. 156-169 ◽  
Author(s):  
Alkistis Kapelouzou ◽  
Stavros Giaglis ◽  
Michalis Peroulis ◽  
Michalis Katsimpoulas ◽  
Petros Moustardas ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Statin Treatment ◽  
Toll Like Receptors ◽  
Atherosclerotic Process ◽  
Hyperlipidemic Rabbit

scholarly journals Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas

2015 ◽  
Vol 9 (1-2) ◽  
pp. 109-116 ◽  
Author(s):  
Jongsik Kim ◽  
Adeel Ahmad ◽  
Joanne Li ◽  
Marina Marjanovic ◽  
Eric J. Chaney ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Ex Vivo ◽  
Early Stage ◽  
Optical Coherence ◽  
Hyperlipidemic Rabbit ◽  
Atherosclerotic Changes
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