Effects of Curcumin in Management of Endometriosis a Hormonal Disorder Disease in Female

A disorder in which endometrial tissues develop outer side the uterus or uterine cavity is called as endometriosis. It affects mainly females in their reproductive years, and is an oestrogen-dependent condition. Endometriosis a gynaecological disease or disorders, occurs in about 10% of female in reproductive age and in upto 50% of females with in-fertility. It is serious type of Hormonal disease or disorders in female which is caused due to hormonal imbalance these diseases totally change the quality of womens life. Decreased quality of life is the most significant predictor of direct health care and total costs so avoid this next step greater way to take care “Prevention is always better than cure”. Curcumin is a natural polyphenolic compound extracted from the spice, turmeric and has been reported to evidence anti-inflammatory (agent which reduce inflammation), antioxidant (the agent which reduce oxidation), and anti-proliferative properties via the modulation of multiple cellular. However, it remains to be determined whether effect of curcumin affects in the management of process of endometriosis. Turmeric contain especially its most active compound Curcumin have many scientifically proven health benefits, it’s a potent Anti-inflammatory and antioxidant and may also help improve symptoms of endometrosis.

Impact of COVID-19 on gynaecological patient care: results of patient’s survey with 327 patients

Purpose The pandemic SARS-CoV-2 poses new and unprecedented challenges for health care systems on a national and global level. Although the current situation has been going on for more than 1 year, there is limited data on the impact of the pandemic on general hospital and medical practice care. This survey captures the perspective of patients with gynaecological diseases of this impact. Methods Using a paper-based questionnaire, 327 patients were asked about medical care and their experiences during the pandemic at the University Hospital Bonn and the University Hospital Charité Berlin. The study was performed from the 1st June to 30th September 2020. Results A total of 327 patients participated in the study: 156 stated to have been tested for coronavirus, and 1 patient reported a positive test. 41.3% of the patients felt insecure about the current situation, 30.4% were concerned about the risk of infection during the hospital stay. The pandemic-specific measures in hospitals and medical practices unsettled 6.8% of patients. 18.1% of patients feared that their gynaecological disease would not be treated adequately due to the pandemic. 55.7% of patients reported that their confidence in their physicians has increased during the pandemic. Conclusion The results show that patients’ confidence in the healthcare system and the physicians acting significantly increased during the COVID-19 crisis. Transparent and comprehensive information policy regarding actions and restrictions within the COVID-19 crisis eases patients concerns and improves patients’ confidence in their physicians, which is crucial for a successful treatment’s outcome.

“The bloodiness and horror of it”

In this work, I explore pain descriptions by women who live with the life-altering gynaecological disease of endometriosis. This condition causes incapacitating pain, which tends to be dismissed and normalised as part of the female condition (Cumberbatch, 2019). My aim is to explore the general patterns of pain conceptualisation by women with endometriosis and outline how an in-depth examination of salient elements of narrative scenarios may contribute towards providing a comprehensive understanding of the pain experience. I first examine patterns of metaphorical pain collocates from a corpus generated from online forum contributions. Following this, I explore metaphorical scenarios of pain, focusing on stories that reference popular texts or genres from a conceptual integration perspective. I argue that the combination of metaphor analysis of naturally-occurring data and conceptual intertextuality and interdiscursivity analysis in the metaphorical scenarios of elicited data constitute a methodological niche that allows a holistic assessment of the pain that can potentially be used in consultations and may help tackle the alarming diagnosis delay of endometriosis, which is currently 7.5 years.

Association between cervical dysplasia and female genital schistosomiasis diagnosed by genital PCR in Zambian women

Background Female genital schistosomiasis (FGS) is a neglected tropical gynaecological disease that affects millions of women in sub-Saharan Africa (SSA). FGS is caused by Schistosoma haematobium, a parasitic carcinogen involved in the pathogenesis of squamous cell carcinoma of the bladder. Cervical cancer incidence and mortality are highest in SSA, where pre-cancerous cervical dysplasia is often detected on screening with visual inspection with acetic acid (VIA). There are no studies evaluating the association between VIA positivity and FGS diagnosed by genital PCR. Methods Women were recruited from the Bilharzia and HIV (BILHIV) study in Zambia a community-based study comparing genital self-sampling to provider obtained cervicovaginal-lavage for the diagnosis of FGS in women aged 18–31. FGS was defined as positive Schistosoma DNA from any genital PCR. Urogenital schistosomiasis diagnostics included urine circulating anodic antigen, urine microscopy and portable colposcopy. Participants were offered cervical cancer screening using VIA at Livingstone Central Hospital. Associations of PCR confirmed FGS and other diagnostics with VIA positivity were assessed using multivariable logistic regression. Results VIA results were available from 237 BILHIV participants. A positive Schistosoma PCR in any genital specimen was detected in 14 women (5.9%), 28.6% (4/14) of these women had positive VIA compared to 9.0% without PCR evidence of schistosome infection (20/223). Schistosoma PCR positivity in any genital specimen was strongly associated with VIA positivity (OR: 6.08, 95% CI: 1.58–23.37, P = 0.02). Conclusions This is the first study to find an association between FGS and positive VIA, a relationship that may be causal. Further longitudinal studies are needed.

A comparative study on the effects of various factors to the revalence of pelvic inflammatory disease in North central Nigeria

Pelvic inflammatory disease is a gynaecological disease that affects the upper genital organs of reproductive age females. It is a disease associated with clinical sequalae such as tubal blockage, oophoritis and cervicitis which are said to result to high rate of disease (such as female infertility) and deaths among the females. This study therefore attempts to evaluate the association of various factors to high prevalence of pelvic inflammatory disease among women residing in developing countries such as Nigeria. Questionnaires were administered to all women enrolled for this study too obtain their data. Seven hundred and twenty (720) patients out of 1170 patients enrolled for this study were recorded to be pelvic inflammatory disease patients, of which 380(85%) were rural dwellers; 452(87.6%) were ignorant of pelvic inflammatory disease and were thus easily prone to the disease; 285(86.4%) were within the reproductive ages of 25-29 years; 350(85.2%) previously had urinary tract infection a year ago; 496(85.8%) and 343(83.5%) were both married and uneducated females. The high prevalence of pelvic inflammatory disease recorded in this study is due to certain predisposing factors practiced among females in their reproductive ages, hence it is necessary for government to enforce certain measures such as establishment of free education, continuous awareness of pelvic inflammatory disease and establishment of free medical check up to help prevent and control the spread of pelvic inflammatory disease.

Biomarkers of endometriosis: How far have we come and where are we going?

Endometriosis is a common gynaecological disease that is characterized by endometrium-like tissue outside the uterine cavity. Endometriosis significantly compromises the quality of life of women and is a major cause of infertility. The gold standard for diagnosis of endometriosis is visual inspection by laparoscopy, which significantly prolongs the time to final diagnosis. This lack of non-invasive diagnostic approaches is why the discovery of biomarkers for endometriosis has been defined as a research priority. In this report, we describe hypothesis-driven and hypothesis-generating approaches for biomarker discovery, along with some important potential biomarkers of endometriosis and their diagnostic characteristics, sensitivities, and specificities. Finally, we present our perspective on the discovery of biomarkers for endometriosis, and discuss some results from our previous and more recent studies. Future studies must focus on improving patient quality of life rather than on discovering significant differences, and therefore close collaboration between clinicians and pre-clinical researchers is essential.

CC and CXC chemokines play key roles in the development of polyomaviruses related pathological conditions

It has been reported that polyomaviruses are the microbes which can be a cause of several human pathological conditions including cancers, nephropathy, progressive multifocal leukoencephalopathy and gynaecological disease. Although investigators proposed some mechanisms used by the viruses to induce the disorders, the roles played by chemokines in the pathogenesis of polyomaviruses infections are yet to be clarified. This review article investigated recent studies regarding the roles played by chemokines in the pathogenesis of the polyomaviruses infections. The research in the literature revealed that CXC chemokines, including CXCL1, CXCL5, CXCL8, CXCL9, CXCL10, CXCL11, CXCL12 and CXCL16, significantly participate in the pathogenesis of polyomaviruses. CC chemokines, such as CCL2, CCL5 and CCL20 also participate in the induction of the pathological conditions. Therefore, it appears that CXC chemokines may be considered as the strategic factors involved in the pathogenesis of polyomaviruses.

Association Between Cervical Dysplasia and Female Genital Schistosomiasis Diagnosed by Genital PCR in Zambian Women

Background: Female genital schistosomiasis (FGS) is a neglected tropical gynaecological disease that affects millions of women in sub-Saharan Africa (SSA). FGS is caused by Schistosoma (S.) haematobium, a parasitic carcinogen involved in the pathogenesis of squamous cell carcinoma of the bladder. Cervical cancer incidence and mortality are highest in SSA, where pre-cancerous cervical dysplasia is often detected on screening with visual inspection with acetic acid (VIA). No studies have evaluated the association between VIA positivity and FGS diagnosed by genital PCR. Methods: Women were recruited from the BILHIV study in Zambia, which compared genital self-sampling to provider obtained cervicovaginal-lavage for the diagnosis of FGS in women aged 18-31. FGS was defined as positive Schistosoma DNA from any genital PCR. Urogenital schistosomiasis diagnostics included urine circulating anodic antigen, urine microscopy and portable colposcopy. Participants were offered cervical cancer screening using VIA at Livingstone Central Hospital. Associations of PCR confirmed FGS and other diagnostics with VIA positivity were assessed using multivariable logistic regression.Results: VIA results were available from 237 BILHIV participants. A positive Schistosoma PCR in any genital specimen was detected in 14 women (5.9%), 28.6% (4/14) of these women had positive VIA compared to 9.0% (20/223) without PCR evidence of schistosome infection. Schistosoma PCR positivity in any genital specimen was strongly associated with VIA positivity (OR: 6.08, 95% CI: 1.58-23.37, P=0.02). Conclusions: This is the first study to find an association between FGS and positive VIA, a relationship that may be causal. Further longitudinal studies are needed.

Endometriosis Is Associated with a Significant Increase in hTERC and Altered Telomere/Telomerase Associated Genes in the Eutopic Endometrium, an Ex-Vivo and In Silico Study

Telomeres protect chromosomal ends and they are maintained by the specialised enzyme, telomerase. Endometriosis is a common gynaecological disease and high telomerase activity and higher hTERT levels associated with longer endometrial telomere lengths are characteristics of eutopic secretory endometrial aberrations of women with endometriosis. Our ex-vivo study examined the levels of hTERC and DKC1 RNA and dyskerin protein levels in the endometrium from healthy women and those with endometriosis (n = 117). The in silico study examined endometriosis-specific telomere- and telomerase-associated gene (TTAG) transcriptional aberrations of secretory phase eutopic endometrium utilising publicly available microarray datasets. Eutopic secretory endometrial hTERC levels were significantly increased in women with endometriosis compared to healthy endometrium, yet dyskerin mRNA and protein levels were unperturbed. Our in silico study identified 10 TTAGs (CDKN2A, PML, ZNHIT2, UBE3A, MCCC2, HSPC159, FGFR2, PIK3C2A, RALGAPA1, and HNRNPA2B1) to be altered in mid-secretory endometrium of women with endometriosis. High levels of hTERC and the identified other TTAGs might be part of the established alteration in the eutopic endometrial telomerase biology in women with endometriosis in the secretory phase of the endometrium and our data informs future research to unravel the fundamental involvement of telomerase in the pathogenesis of endometriosis.