Ag-Catalyzed Ring-Opening of Tertiary Cycloalkanols for C-H Functionalization of Cyclic Aldimines

We firstly describe a silver-catalyzed direct C–H functionalization of cyclic aldimines with cyclopropanols and cyclobutanols via radical-mediated C-C bond cleavage strategy. The desired products were generated in decent yields with...

Iridium-catalyzed highly stereoselective deoxygenation of tertiary cycloalkanols: stereoelectronic insights and synthetic applications

The sterically large iridium hydride delivers its hydride to the carbocation from the sterically least hindered direction of attack.

Silver-catalyzed C2-selective direct alkylation of heteroarenes with tertiary cycloalkanols

A silver-catalyzed regioselective C2-alkylation of heteroarenes with primary radicals produced by tertiary cycloalkanols was developed.

Transition-metal free alkylarylation of acrylamides initiated by radical C–C bond cleavage of the tertiary cycloalkanols

An efficient Na2S2O8-promoted radical cyclization reaction of acrylamides with the tertiary cycloalkanols has been developed. This one pot procedure involves a tandem C–C bond cleavage and two C–C bonds formation process.