Analisis Perbandingan Produktifitas dan Efsiensi Pengiriman Material pada Sistem Aging dan Sistem Scheduling Route Menggunakan Analisis Produktifitas dan Data Envelopment Analysis (DEA)

Productivity and efficiency are two main things that can be used as benchmarks for success from the Delivery section of the SCM department. Productivity is the main point in assessing whether the Delivery system in the warehouse is feasible or has not reached its target. In the last few periods after carrying out a track record of the historical data of the shipment of goods. It was found that in one week there were frequent deliveries to the same user drop point location, meaning that this could lead to waste & waste from inefficient work. In connection with that, a new system is implemented, the scheduling system, which is a delivery system for delivering material with a predetermined schedule every week. This research is intended to produce a productivity analysis that shows whether this new scheduling system can increase productivity and delivery efficiency when compared to an aging system or vice versa by using a productivity analysis methodology and efficiency level benchmarking using data envelopment analysis (DEA). The results of the aging system productivity analysis have a better value, namely 34%, while the scheduling system is 26%, but scheduling has a shorter distance so it can make savings. Meanwhile, in comparison to efficiency using benchmark factors, it is found that the aging system is more efficient with an optimum value of 1, and scheduling of 0.9855535 is considered inefficient.

Optimal control of aging in complex networks

Many complex systems experience damage accumulation, which leads to aging, manifest as an increasing probability of system collapse with time. This naturally raises the question of how to maximize health and longevity in an aging system at minimal cost of maintenance and intervention. Here, we pose this question in the context of a simple interdependent network model of aging in complex systems and show that it exhibits cascading failures. We then use both optimal control theory and reinforcement learning alongside a combination of analysis and simulation to determine optimal maintenance protocols. These protocols may motivate the rational design of strategies for promoting longevity in aging complex systems with potential applications in therapeutic schedules and engineered system maintenance.

Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program

The mitochondria of various tissues from mice, naked mole rats (NMRs), and bats possess two mechanistically similar systems to prevent the generation of mitochondrial reactive oxygen species (mROS): hexokinases I and II and creatine kinase bound to mitochondrial membranes. Both systems operate in a manner such that one of the kinase substrates (mitochondrial ATP) is electrophoretically transported by the ATP/ADP antiporter to the catalytic site of bound hexokinase or bound creatine kinase without ATP dilution in the cytosol. One of the kinase reaction products, ADP, is transported back to the mitochondrial matrix via the antiporter, again through an electrophoretic process without cytosol dilution. The system in question continuously supports H+-ATP synthase with ADP until glucose or creatine is available. Under these conditions, the membrane potential, ∆ψ, is maintained at a lower than maximal level (i.e., mild depolarization of mitochondria). This ∆ψ decrease is sufficient to completely inhibit mROS generation. In 2.5-y-old mice, mild depolarization disappears in the skeletal muscles, diaphragm, heart, spleen, and brain and partially in the lung and kidney. This age-dependent decrease in the levels of bound kinases is not observed in NMRs and bats for many years. As a result, ROS-mediated protein damage, which is substantial during the aging of short-lived mice, is stabilized at low levels during the aging of long-lived NMRs and bats. It is suggested that this mitochondrial mild depolarization is a crucial component of the mitochondrial anti-aging system.

Effect of Different Aging System on Microstructure and Mechanical Properties of X2A66 Alloy

Through a series of mechanical properties tests and microstructure observation, the effects of artificial heat treatment (AA), pre-stretching aging (PA) and pre-stretching creep aging (PCA) treatment on the precipitation phase type and mechanical properties of X2A66 aluminum-lithium alloy were studied. The results show that compared with AA, PA treatment promotes the uniform precipitation of high-density T1 phase, so that the yield strength, tensile strength and elongation of the alloy reach 593.4Mpa, 610.8Mpa, 10.7%. Further, the creep aging treatment on the basis of the pre-deformation can further increase the strength (613.6Mpa, 628.9Mpa) of the alloy with a slight decrease in the elongation (10.3%).