AbstractWe establish a reduction principle to derive Li–Yau inequalities for non-local diffusion problems in a very general framework, which covers both the discrete and continuous setting. Our approach is not based on curvature-dimension inequalities but on heat kernel representations of the solutions and consists in reducing the problem to the heat kernel. As an important application we solve a long-standing open problem by obtaining a Li–Yau inequality for positive solutions u to the fractional (in space) heat equation of the form $$(-\Delta )^{\beta /2}(\log u)\le C/t$$
(
-
Δ
)
β
/
2
(
log
u
)
≤
C
/
t
, where $$\beta \in (0,2)$$
β
∈
(
0
,
2
)
. We also show that this Li–Yau inequality allows to derive a Harnack inequality. We further illustrate our general result with an example in the discrete setting by proving a sharp Li–Yau inequality for diffusion on a complete graph.