Disproportioning of toluene on Pd-H Mordenite catalyst

Synthetic mordenite ceolite was decationized and dealuminated with 2N hydro-chloride acid, calcinated in the temperature range of 500−600 oC. Obtained samples of H-mordenite and initial Na-mordenite have been analyzed on the X-ray phase difractometer and according to the X-ray patterns it was defined that the silica module of elasticity of H-mordenite comprised 17, and the crystallinity reduced for 2-3 %. Furthermore, obtained sample of ceolite catalyst of H-mordenite was modified with Pd+2 ions up to 0.3, 0.5 and 0.8 % by the mass. Catalyst activity of sythesized H-mordenites and metall-ceolite catalysts containing various amount of Pd+2 metal cations was studied in the reaction of disproportioned toluene to the benzole and xylol in the temperature 300−380 °C, H2: CH = 3: 1 mole in the rate of 3.1 h-1. It was defined that the catalyst of 0.5 % Pd-H-mordenite (SiO2: Al2O3 = 17) shows better activity for this reaction.

Synthesis, Characterization and Antimicrobial Evaluation of Novel Dimethyl Triazene Incorporated Phenylamino Pyrimidine Derivatives

A series of novel (E)-4-(4-(3,3-dimethyltriaz-1-en-1-yl)phenyl)-N-phenylpyrimidin-2-amine derivatives have been synthesized from the condensation of (E)-3-(dimethylamino)-1-(4-(E)-3,3-dimethyltriaz- 1-en-1-yl)phenyl)prop-2-en-1-one with several guanidinium hydro-chloride. The newly synthesized compounds were examined for in vitro antimicrobial activity against some antibacterial and fungal strains. The synthesized compounds were characterized by 1H NMR, 13C NMR, IR, mass and elemental analyses.

Simultaneous Determination of Dextromethorphan and Promethazine in Pharmaceutical Syrups by Rapid HPLC Method

A simple, precise and accurate method is validated for the simultaneous determination of two nitrogenous compounds dextromethorphan hydrobromide and promethazine hydro-chloride, which are commonly used as active ingredients in pharmaceutical syrups. The chromatographic conditions comprised of a classical C8-type stationary phase (250 × 4.6 mm, 5 μm) with a mobile phase consisting of 3 g of sodium lauryl sulfatein a mixture of 400 ml of water and 600 ml of acetonitrile along with 0.5 g of ammonium nitrate as additional agent. The solution pH 2.0 was adjusted with glacial acetic acid. The flow rate was 1 ml/min; the detection was carried out at 280 nm under temperature of 25o. The retention time of dextromethorphan was 8.5 min and 9.9 min for promethazine. The method was validated for specificity, accuracy, precision and linearity. The results indicate that the drugs are susceptible to photo-degradation. All the peaks of degraded products were resolved from the two active pharmaceutical ingredients with significant different retention times.

RP-HPLC Method for Simultaneous Estimation of Ciprofloxacin and Phenylephrine in Combined Dosage Forms

A new, simple, rapid, selective, precise and accurate gradient RP-HPLC method has been developed for simultaneous estimation of Ciprofloxacin and Phenylephrine Hydrochloride in combined dosage form. The separation was achieved by using Thermic Hypersil C column (250 mm x 4.6 mm, 5 µm particle size) coupled with a guard column of same material, in mobile phase Acetonitrile: Methanol: Phosphate Buffer pH 6 (10: 65: 25, v/v/v). The flow rate was 1.0 ml/min and the separated drugs were detected using UV detector at the wavelength of 220 nm. The analysis was performed at room temperature (37 ± 2 ºC). The retention time of Ciprofloxacin and Phenylephrine Hydrochloride was noted to be 6.63 and 4.49 min, respectively, indicative of rather shorter analysis time. The method was validated as per ICH guidelines. The calibration curves were linear (r2 > 0.9980) over a concentration range from 0.5 – 4.0 μg/ml and 2.0 – 5.5 μg/ml for Ciprofloxacin and Phenylephrine Hydrochloride, respectively. The relative standard deviation (RSD) was < 2.0% and the mean recovery was 100.51 ± 0.34 and 100.81 ± 0.80 for Ciprofloxacin and Phenylephrine Hydro-chloride, respectively. The proposed method was found to be accurate, reproducible, and consistent. It was successfully applied for the analysis of these drugs in marketed formulations and could be effectively used for the routine analysis of formulations containing any one of the above drugs, or a combination, without any alteration in the chromatographic conditions.

Basic Aspects of the Pharmacodynamics of Tolperisone, A Widely Applicable Centrally Acting Muscle Relaxant

Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone (spasticity) and related pains of different origin. In the present review, basic pharmacodynamic effects measured on whole animals, analyses of its actions on cell and tissue preparations and molecular mechanism of action on sodium and calcium channels are summarized as recently significantly new data were reported.

Synthesis, Structural Studies of Some New Transition Metals Complexes of Semicarbazide hydro chloride Schiff Base Derivatives

A new series of transition metal complexes of Cu(II), Ni(II), Co(II) and Fe(III) have been synthesized from the Schiff base (L1) and (L2) derived from Semicarbazide hydro chloride and 4-chlorobenzaldehyde or 4-bromobenzaldehyde. The structural features have been arrived from their elemental analyses, magnetic susceptibility, molar conductivity, IR, UV-Vis. and 1H NMR spectral studies. The data show that the complexes have composition of [M(L)2](NO3)2 and [Fe(L)2 (NO3)2](NO3) where the M=Co(II),Ni(II) and Cu(II) ;L=L1and L2 type. The magnetic susceptibility and UV-Vis spectral data of the complexes suggest a square planer geometry for Co(II) and Cu(II) but Fe(III) octahedral geometry and Ni(II) tetrahedral geometry around the central metal ion.Hyper Chem-6 program has been used to predict structure geometries of compounds in gas phase .The electrostatic potential of the free ligands were calculated to investigate the reactive sites of the molecules .The heat of formation(?Hf ?) and binding energy(?Eb) at 298K for the free ligands and its metal complexes were calculated by using PM3 method.