A CLINICAL CASE OF SEMINAL CARCINOMA IN A GERMAN SHEPHERD MALE

The article describes a clinical case of testicular neoplasia – seminal carcinoma in male German shepherd. This neoplasia was found in annually medical checkup of working dogs. An indurated, space-occupying, non-tender mass was found in the ill testicle by touch. An ultrasound investigation of the testicles and prostatic gland was made as differential diagnostics and according to the results provisional diagnosis was made – testicular neoplasia. The dog was successfully operated on, and during the orchiectomy, material was collected for histological examination to make a final diagnosis. Morphological diagnosis: the histology pattern is most consistent with the classical seminal carcinoma with lymphocytic infiltration.

Skeletal Muscle–Adipose Tissue–Tumor Axis: Molecular Mechanisms Linking Exercise Training in Prostate Cancer

Increased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these effects are mediated by ET-induced synthesis and secretion of several proteins, known as myo- and adipokines. Together, myokines and adipokines may act in an endocrine-like manner to favor communication between skeletal muscle and WAT, as they may work together to improve whole-body metabolic health. This crosstalk may constitute a potential mechanism by which ET exerts its beneficial role in the prevention and treatment of PCa-related disorders; however, this has not yet been explored. Therefore, we reviewed the current evidence on the effects of skeletal muscle–WAT–tumor crosstalk in PCa, and the potential mediators of this process to provide a better understanding of underlying ET-related mechanisms in cancer.

Prostate Artery Embolisation as a Palliative Care in a Patient with Prostate Cancer: A Case Report

Introduction: Prostate artery embolization is an emerging technique, that appears to be a promising option in the management of benign prostatic hyperplasia for patients unsuitable for surgery. Prostate artery embolization, similar to all other interventions, is not a suitable treatment for all patients with this disease. It is indicated as a minimally invasive option in patients unfit to undergo trans urethral resection of prostate. Case Report: A 78-year-old male suffering from castrate resistant prostate cancer and on treatment with Abiraterone plus prednisolone presented to the Uro-oncological services of the hospital with difficulty to void, incomplete voiding, and sense of incomplete voiding. He had other medical co-morbidities which included Diabetes mellitus, hypertension, and ischaemic heart disease. His cardiac ejection fraction was 25% and was advised not to undergo any surgical procedure. Serum creatinine on admission was 2.2 mg% and serum PSA were 26.5 ng/ml. Under local anaesthesia, using retrograde Seldinger’s technique right common femoral arterial access was obtained and 6F vascular introducer sheath was placed. Bilateral pelvic angiogram was performed, each of the prostatic arteries was superselectively catheterized and the prostatic gland was embolized using PVA (polyvinyl alcohol) particles 200m. Post catheter removal the patient voided well with a maximum flow of 14.5 ml/sec. Conclusion: Prostate artery embolization can successfully treat complications associated with prostate cancer such as LUTS, urinary retention and haematuria with a low risk of serious adverse events.

Peculiarities of hemostasis in transurethral resection of prostatic gland using fybrinolysis inhibitor

Tissue plasminogen activator being the most important component part of fybrinolysis is producing and accumulating in the prostatic gland. In surgical treatment of prostate an increased bleeding often occurs during the surgical operations on the prostate during as well as in post-operative period. General and local fybrino- lysis increase is in case among the reasons of haemor-ragy as a result of mechanical action on prostatic gland tissue in the process of an operation. It is suggested the use of Tranexam a tranexamic acid drug to neutralize an increasing fybrinolysis. In 83 patients with benign prostate hyperplasia, which underwent by transurethral resection of prostate, significantly positive effect of Tranexam was found, prescribed in therapeutic doses before operation, during operation and in early postoperative period.

MEASUREMENT OF NORMAL SIZE OF PROSTATIC GLAND IN NORMAL SUDANESE MEN MARCH- OCTOBER 2019

Background: The prostate may become larger and begin to cause problems as male ages. Ultrasound is a commonly used imaging modality for the assessment of the prostate. Objective: The aim of this study was to identify the normal measurements (volume and diameters) of the prostate gland in Khartoum state Sudan in normal Sudanese. Method: This descriptive study of the study was done in Sudan teaching hospital, from March –to October 2019. 60 patients were randomly selected, their age ranged from 20 to 60 years; patients with symptoms related to prostate pathologies were excluded. Transabdominal ultrasound scanning by3.5 MHz probes was performed. And the Maximum length, width, and depth of the prostate diameters were obtained as well as the prostate volumes. Results: The results of the study revealed that the prostate length, width and thickness Diameters mean values were (4.88) cm, (3.37) cm, and (4.55) cm respectively, the Mean prostate volume obtained from the above parameters was18.65 ml. The study also showed that there was an increase in the prostate volume in relation to an increase in the patient's age and weight. Transabdominal ultrasound is a respectful approach and should be used confident pathologies among Sudanese and for normal measurements.

Modifying effect of triadimefon on the development of preneoplastic lesions and tumours in rat multi-organ carcinogenesis

Throughout life, the human body is exposed to multiple environmental carcinogens that may stimulate carcinogenesis in different organs. Critical place among these carcinogens belongs to nitroso compounds. Triadimefon belongs to the chemical class of triazoles that are widely used as fungicides in pesticides and medicinal products. Objective is to investigate the effect of triadimefon on the development of preneoplastic lesions of the tissues and tumours in carcinogenesis induced in different organs by nitroso compounds. Materials and Methods. Experiments were performed in male Wistar Han rats in which nitroso compounds - N-nitrosodiethylamine, N-methylnitrosourea, N-nitrosobis(2-hydroxypropyl) amine induced multi-organ carcinogenesis according to the N.Ito. protocol. Triadimefon at the doses: 16.0 and 80.0 mg/kg body weight that corresponded to the no-observed-effect and observed effect level by carcinogenic effect were administered intragastrically on a daily basis for 20 weeks. Clinical studies were conducted throughout the experiment. The general condition of animals, their body weight and body weight gain were assessed. After necropsy, gross examination, including aberrant multiple crypts of the colonic mucosa, and histological examinations were conducted. Nodules positive for γ-glutamyl transpeptidase (γ-GTP) were determined by histochemistry in the hepatic tissue. Results. No clinical signs of toxic action of triadimefon in rat body induced by nitroso compounds to carcinogenesis were established. No specific organotrophic action of triadimefon was found by changes in the internal organ weight, except for liver. High dose resulted in the increase of liver weight, as well as in the number and size of γ-GTP positive nodules suggesting an increase in the pool of transformed hepatocytes. Histological examination of internal organs allowed detecting proliferative processes that are criterial markers of carcinogenicity of chemical substances upon their study in multi-organ model. The tendency to the increase in the rate of dose-dependent thyroid adenoma has been established. Increase in the rate of epithelium hyperplasia of oesophagus and forestomach, prostatic gland, as well as the total rate of benign tumours in different organs of animals on the tumour-inducing dose of triadimefon was found. The rate of malignancies in these animals do not differ from the control. Conclusion. The tumour-inducing dose of triadimefon shows weak promotor effect on the development of preneoplastic lesions of tissues of the thyroid gland, liver, oesophagus and forestomach, prostatic gland, as well as on the development of benign tumours in rats induced by carcinogenic nitroso compounds. No-observed-effect level of triadimefon by oncogenic effect established in chronic experiments ensures its safety upon exposure in the body of rats initiated by carcinogenic nitroso compounds. Regulations developed on this parameters ensure oncological safety of its use in human.