Due to the COVID-19 pandemic, educational institutions in the Philippines rapidly introduced widespread online learning to ensure safety of learners. The purpose of this study was to explore the possible relationship of social determinants of health with COVID-19 specific psychological distress and the readiness of Filipino students to learn online. Researchers conducted an online survey of 30 college students from the Psychology program of Ateneo de Davao University in Davao City, Philippines. Results showed that students experienced mild (53.3%) to severe (36.7%) levels of COVID-19 specific psychological distress. COVID-19 specific psychological distress and readiness for online learning was not significantly correlated, r (30) = -.18, p = .35. Among social determinants of health, only living with family members was significantly associated with readiness for online learning, r (30) = -.37, p = .046. These findings showed promising findings on how social determinants of health may be associated with distress and online learner readiness during a global pandemic. Future studies may elaborate on the subjective experiences of students. Finally, this pilot study serves as a basis for the development of school programs that address students’ mental health and promote online learning readiness of students who are experiencing unique learning circumstances.