In 2014, a deadly epidemic of Ebola hemorrhagic fever ravaged three countries in West Africa. While the disease barely hit the United States, it caused widespread panic that sometimes threatened the safety of African immigrants in the United States. Five years later, a global pandemic of a novel coronavirus, later named COVID-19, quickly picked up speed around the world. In the face of a serious and very real threat, many Americans ignored the warnings and a vocal minority even insisted that the pandemic was not real. While the particulars of each of these examples might be quite different, they have something very important in common: science denial. This introductory chapter provides an overview of how such widespread science denialist views come into existence and how they spread. The authors outline the eight chapters of this book, which go into depth on different psychological mechanisms behind this phenomenon. Finally, they provide a preview of some of the solutions we have devised in response to this grave problem.