Geographic information systems or geographic information science is a combination of computer-mapping capabilities with additional database management/data analysis tools. GIS is widely used in various sectors such as environmental science, urban planning, agricultural applications etc. Public health is another focus area, where GIS has been used for research and practice areas such as epidemic surveillance and monitoring, among others. The journey of use of GIS in public health spans more than a century and GIS application in public health has evolved from the simple maps to the higher level geostatistical analysis and interactive WebGIS in recent times. GIS is an analytical tool which differs from conventional computer-assisted mapping and any statistical analysis programs in its ability to analyze complex data and visual presentation of spatial data. Specialized GIS techniques such as network analysis, location-allocation models, site selection, transportation models, and geostatistical analysis are well established and used in many developed and developing nations. Unfortunately owing to the high cost of licensed software and specialized skills for advanced data analysis, use of these techniques is limited mainly for the research and by few experts. GIS is proved to be useful for various public health practices and research purposes including epidemiological surveys/investigation, implementation research, program/policy decision making and dissemination of information. The advantage of using GIS is that maps provide an added dimension to data analysis, which helps in visualizing the complex patterns and relationships of public health issues, thus many unanswered questions in public health, can be understood well through use of GIS techniques. Use of GIS in public health is an application area still in its infancy. Wider use of GIS for public health practice such as program planning, implementation and monitoring in addition to building evidence base for the policy making will help reduce inequities in health and provide universal healthcare. Overall, GIS is a helpful and efficient tool especially for public health professionals working in low resource settings. In the future with inclusion of advanced GIS technology like WebGIS can help reach the goal of optimal health care services globally.