When thinking of smell, we usually consider it only as one of the five senses. Compared to the rest of senses, smell has been underestimated. By conducting a research, we will be able to discover how mistaken we are. The human sense of smell is more powerful than it's usually given credit for and plays a major role in human health and behavior than many experts in the field are aware of the sense of smell is present in our daily activities and, depending on the gender, perception may differ, as well as from the anatomical structure of the olfactory organ between genders to the stimulus of the odor. The fragrances determine our everyday food choices, places where we choose to spend with our life partner. Scents can determine our sexual behavior, in building infant-parent connection and create our habits as well. It can also warn us against the selection of food, persons, also death. In this case, the loss of smell can be related with an olfactory organ dysfunction, but as well can have an endocrine, genetic or psychical basis. The olfactory dysfunction can change our habits and basically our whole life. It is irrefutable that while talking about smell which we consider as one of the senses, we can talk about sensuality which broadly covers the relationship between smell and perception of reality. Sensuality in a general sense can be defined as the perception of the surrounding things through the senses, as sensory pleasure, and unlike sexuality, which can be translated as the reception of biological, psychological and physical stimuli. Aim of the study: Currently all of our senses are mostly well known. We are trying to consider the topic from many different sides to make ourselves more and more advanced. We are trying to unite a couple of subjects to prove that we can connect one with another to explore how advanced our organism is. In this research we are trying to look closely at the two different topics and glue them together. Trying to improve and update the connection between the sense of smell and sensuality. This is possible due to the relationship between the smell and the part of our brain responsible for memories and memory, i.e. the limbic system. In this way, we can process the aroma stimulus into memories, we associate smells with specific situations, places, people or things [1]. Therefore, the objectives we have in this study are the following: The nose as an olfactory organ and the anatomical differences as to structure; the olfactory system is strictly connected with the sense of smell; sex, as a gender, something that make us different from each other; physical and psychological disorders and influence of smell. Taking into consideration the amount of work and research on the sense of smell and the still uncertain issues related to it, it is certain how important it is for life and science to fully understand its properties. Over time, with the development of science and technology, there is an increasing wish to learn about such a complicated machine as the human body. Material and methods: In the first part of this research, we will gather all the information that is commonly available so far in the international bibliography, as well as the achievements and utilities obtained to date. Following we will analyse all the new concepts that exist on the topic of sense of smell in connection with sex and sensuality, also how the smell can change due to various disorders and try to summarise it based on the latest research.