With rapid changes taking place in today's society, individuals need more than ever to be equipped with tools that will assist them to cope with the changes they are faced with within multitude domains of their lives: school, work and social environments. As learning is a life- long process that touches and interacts with many domains of one's individual life and overall functioning, individuals must be flexible and able to adapt to the everyday changes around them. More specifically in education, students over the last decade with increased technological advances, have opportunities that extend beyond the brick -and- mortar traditional learning environment, thus indicated as “blending learning”; a combination of web-based teaching and learning experiences along with structured individual and collaborative interaction among students and their teachers. The i2Flex model, piloted at the American Community Schools of Athens, Greece will be examined and illustrate how learning within this framework, assists students in being flexible, adaptive and skilled 21st century learners.