Pain is multidimensional, complex; it affects the ontological structures of the human being and exceeds spatio-temporal boundaries. Therefore, it is universally felt with an impact in the past, moving to the present, and projecting to the future. There are efforts to ease or completely eliminate the impact of pain, however, a good understanding of its biological and anthropological dimensions is necessary for proper orientation of such undertakings. This article identifies some social, cultural, medical-scientific, and individual factors that account for the changes in modes of experiencing and managing pain. It posits that there is a general unpreparedness on the physical, psychological, and spiritual levels for continued pain in the future. It thus analyses factors that need to be learnt in order to promote favourable alterations in mental attitudes, pain sensitivity, and tolerance to pain. Preparing for a future of pain requires interdisciplinary reflection on the bodily, emotional, and spiritual components that constitute the pain experience so as to re-direct its trajectory.