Dextromethorphan-quinidine is helpful for pseudobulbar affect disorder in stroke patients

An informed consent article using Hammond FM, Alexander DN, Cutler AJ, et al. PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury. BMC Neurology. 2016;16:89. https://doi.org/10.1186/s12883-016-0609-0 for a patient with pseudobulbar affect following stroke.

Oral budesonide is an effective alternative to prednisone for treatment of autoimmune hepatitis

A clinical decision report using: Manns MP, Woynarowski M, Kreisel W, et al. Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis. Gastroenterology. 2010;139(4):1198-1206. https://doi.org/10.1053/j.gastro.2010.06.046 for a patient with autoimmune hepatitis developing septic arthritis secondary to prednisone therapy.

How much penicillin is needed to treat early syphilis in people living with HIV?

A clinical decision report using: Andrade R, Rodriguez-Barradas MC, Yasukawa K, Villarreal E, Ross M, Serpa JA. Single Dose Versus 3 Doses of Intramuscular Benzathine Penicillin for Early Syphilis in HIV: A Randomized Clinical Trial. Clin Infect Dis. 2017;64(6):759-764. https://doi.org/10.1093/cid/ciw862 to inform treatment of syphilis for a person living with HIV with multiple socioeconomic barriers to care.

Implementation of high intensity interval training offers opportunity to enhance glycemic control in patients with type 2 diabetes

A clinical decision report using: Alvarez C, Ramirez-Campillo R, Martinez-Salazar C, et al. Low-Volume High-Intensity Interval Training as a Therapy for Type 2 Diabetes. Int J Sports Med. 2016;37(9):723-729. https://doi.org//10.1055/s-0042-104935 for a patient with newly diagnosed diabetes mellitus type 2.

Weight loss as sole treatment for obstructive sleep apnea in a patient with significant risks posed by daytime sleepiness

A clinical decision report using: Kuna ST, Reboussin DM, Borradaile KE, Sanders MH, Millman RP, Zammit G, Newman AB, Wadden TA, Jakicic JM, Wing RR, Pi-Sunyer FX, Foster GD; Sleep AHEAD Research Group of the Look AHEAD Research Group. Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes. Sleep. 2013 May 1;36(5):641-649A. https://doi.org/10.5665/sleep.2618 to inform whether weight loss alone can adequately and promptly treat OSA in a patient with high-risk employment and an aversion to more invasive intervention.

The efficacy of a sumatriptan and naproxen combination pill in a patient with chronic migraines who discontinued triptan therapy in the past due to a self-reported poor response to sumatriptan monotherapy

A clinical decision report using: Mathew NT, Landy S, Stark S, et al. Fixed-dose sumatriptan and naproxen in poor responders to triptans with a short half-life. Headache. 2009;49(7):971-982. https://doi.org/10.1111/j.1526-4610.2009.01458.x for a patient with chronic migraines who had self-reported poor response to sumatriptan monotherapy.

Using a single tablet regimen of darunavir, cobicistat, emcitrabine, and tenofovir alafenamide in virally suppressed HIV-1 patients is an adequate treatment option for controlling HIV

A clinical decision report using: Orkin C, Molina JM, Negredo E, et al. Efficacy and safety of switching from boosted protease inhibitors plus emtricitabine and tenofovir disoproxil fumarate regimens to single-tablet darunavir, cobicistat, emtricitabine, and tenofovir alafenamide at 48 weeks in adults with virologically suppressed HIV-1 (EMERALD): a phase 3, randomised, non-inferiority trial. Lancet HIV. 2018;5(1):e23-e34. https://doi.org/10.1016/S2352-3018(17)30179-0 for a patient with viriologically suppressed HIV-1.

Metformin monotherapy is an effective alternative for management of gestational diabetes mellitus in patients refusing insulin monotherapy

A clinical decision report using: Ghomian N, Vahed SHM, Firouz S, Yaghoubi MA, Mohebbi M, Sahebkar A. The efficacy of metformin compared with insulin in regulating blood glucose levels during gestational diabetes mellitus: A randomized clinical trial. J Cell Physiol. 2019;234(4):4695-4701. https://doi.org/10.1002/jcp.27238 for a patient with gestational diabetes mellitus (GDM) who does not wish to undergo insulin monotherapy.

Does HIV status confer a higher risk of acquiring COVID-19? Using Clinical Decision Science to combat patients’ anxiety

A clinical decision report using: del Amo J, Polo R, Moreno S, et al. Incidence and Severity of COVID-19 in HIV-Positive Persons Receiving Antiretroviral Therapy. Annals of Internal Medicine. 2020;173(7):536-541. https://doi.org/10.7326/m20-3689 for a patient with HIV and concerns about COVID-19 for immunocompromised individuals.

Pre-mixed insulin has a similar efficacy to basal-bolus insulin in reducing HbA1c levels in type 2 diabetics

A clinical decision report using: Fulcher G, Roberts A, Sinha A, Proietto J. What happens when patients require intensification from basal insulin? A retrospective audit of clinical practice for the treatment of type 2 diabetes from four Australian centres. Diabetes Research and Clinical Practice, 2015;108(3):405–413. https://doi.org/10.1016/j.diabres.2015.03.004 for a patient with uncontrolled type 2 diabetes.