This chapter examines barriers to economic opportunity and mobility in the United States and offers near- and long-term policies to reduce these barriers. These barriers include high levels of income inequality, unequal access to educational opportunities, residential segregation by income, inadequate investments in children and certain areas, and disparities between economic conditions in rural relative to metro areas. In the near-term, running tight labor markets, infrastructure investment, direct job creation, healthcare and other work supports, and apprenticeships could reduce these barriers. Longer term solutions invoke policy interventions targeting inequality, inadequate housing, income and wage stagnation, nutritional and health support, the criminal justice system, and educational access. It is also crucial to avoid policies that keep opportunity barriers in place, such as reducing the provision of public healthcare, regressive tax cuts, and budget cuts to programs that help low- and moderate-income families.