Impact of the coordination of multiple Lewis acid functions on the electronic structure and vn configuration of a metal center

The number of electrons that a metal center provides to the bonding orbitals for coordination of multiple π-acceptor ligands is not a direct function of the number of ligands, and consideration must be given to the availability of metal orbitals.

Fungicides and Bacillus subtilis against fungi isolated from commercial seed of Side oats grama (Bouteloua curtipendula)

Banderita (<em>Bouteloua curtipendula</em>), produces abundant and appetizing forage for cattle under extreme arid conditions. The demand for its seed in Mexico is a direct function of the potential for the establishment of pastures and therefore, the sanitary quality of this is fundamental. Phytopathogenic fungi affect the seed and establishment of prairies. The objective was to evaluate<em> in vitro</em> the effect of six agrochemicals and one biological against fungi associated with Banderita seed, to reduce losses caused by these. Treatments were carried out in PDA culture medium combined with Captan, Thiophanate-methyl, Mancozeb, Benomil, Prochloraz, Thiabendazole and <em>Bacillus subtilis</em> at concentrations according to the case of 0 (control), 0.005, 0.001, 0.05, 0.01, 0.5, 0.1, 1.5, 10, 100, 150, 200, 250 and 300 mg L-1, against <em>Alternaria alternata</em>, <em>Bipolaris cynodontis</em> and <em>Fusarium incarnatum</em>. The bi-directional colony diameter was measured every 48 h. The effective concentration of 50% was estimated by a non-linear regression model; in relation to the percentage of inhibition of mycelial growth. <em>Bacillus subtilis</em> presented higher mycelial inhibition 97% (P &lt;0.05), followed by Thiophanate-methyl (96%), Prochloraz (94%), Captan (93%) and Mancozeb (92%). Benomyl and Thiabendazole showed low inhibition of fungi with 46 and 37%.<em> B. subtilis</em> and Thiophanate-methyl are the products with the greatest possibility of controlling pathogens associated with Banderita grass seeds.

Novel features of electromagnetic waves in an isotropic degenerate electron-ion plasma

Within the framework of kinetic theory, the nonlinear interaction of electromagnetic waves (EMWs) with a degenerate electron-ion plasma is studied to account for the electron quantum mechanical effects. For this purpose, a specific quantum regime is considered, for which the degenerate electron Fermi velocity is assumed to be taken of the order of group velocity of EMWs. This eventually leads to the existence of nonlinear Landau damping rate for the EMWs in the presence of electron Ponderomotive force. The electrons-ion density oscillations may be arisen from the nonlinear interaction of EMWs, leading to a new type of nonlinear Schrödinger equation in terms of a complex amplitude for electromagnetic pump wave. The profiles of nonlinear damping rate reveal that EMWs become less damped for increasing the quantum tunnelling effects. The electrostatic response for the linear electrostatic waves is also investigated and derived a linear dispersion for the ion-acoustic damping rate. The latter is a direct function of electron Fermi speed and does not rely on the Bohm tunneling effect. The obtained results are numerically analyzed for the two microwaves of different harmonics in the context of nonrelativistic astrophysical dense plasma environments, e.g., white dwarfs, where the electron quantum corrections cannot be ignored.

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation

Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). HIPKs are regulators of various signaling pathways and involved in the pathology of cancer, chronic fibrosis, diabetes, and multiple neurodegenerative diseases. Here, we report the crystal structure of HIPK3 in its apo form at 2.5 Å resolution. Recombinant HIPKs and DYRK1A are auto-activated and phosphorylate the negative elongation factor SPT5, the transcription factor c-Myc, and the C-terminal domain of RNA polymerase II, suggesting a direct function in transcriptional regulation. Based on a database search, we identified abemaciclib, an FDA-approved Cdk4/Cdk6 inhibitor used for the treatment of metastatic breast cancer, as potent inhibitor of HIPK2, HIPK3, and DYRK1A. We determined the crystal structures of HIPK3 and DYRK1A bound to abemaciclib, showing a similar binding mode to the hinge region of the kinase as observed for Cdk6. Remarkably, DYRK1A is inhibited by abemaciclib to the same extent as Cdk4/Cdk6 in vitro, raising the question of whether targeting of DYRK1A contributes to the transcriptional inhibition and therapeutic activity of abemaciclib.

An Investigation of a Supply Chain Model for Co-Ordination of Finished Products and Raw Materials in a Production System under Different Situations

In the production system, the production of a perfect item is essential for existing competitive market situations. To produce a perfect finished product, the quality of a raw material is a crucial issue of a production system. This paper has examined this issue with an insightful production-inventory model of the manufacturer of a deteriorating item selling goods to multiple markets with different selling seasons. We have provided an answer strategy to track down the optimal production plan for raw materials and the ideal creation plan for completed items. Transportation cost was incorporated for transporting the raw material. Marketing of the finished product is another crucial factor for selling products and earning revenues. The main objective of the present study is to adopt a production model in inventory for inferring request capacities for multi-item, multi-outlet circumstances. As of late, much accentuation has been given to the consideration of the control and support of creation inventories of disintegrating things. The demand rate is persistent and holding cost is a direct function of time. This paper has followed an analytical approach to diminish the entire inventory cost. Finally, a sensitivity analysis was performed to study the effect of changes of different parameters of the model on the optimal policy. Moreover, in order to approve the determined models, we have clarified mathematical models and examined affectability.

Tyr is Responsible for the Cctq1a QTL and Links Developmental Environment to Central Corneal Thickness Determination

Central corneal thickness is a quantitative trait with important associations to human health. In a phenotype-driven approach studying corneal thickness of congenic derivatives of C57BLKS/J and SJL/J mice, the critical region for a quantitative trait locus influencing corneal thickness, Cctq1a, was delimited to a 10-gene interval. Exome sequencing, RNAseq, and studying independent mutations eliminated multiple candidate genes and confirmed one. Though the causative gene, Tyr, has no obvious direct function in the transparent cornea, studies with multiple alleles on matched genetic backgrounds, both in isolation and genetic complementation crosses, confirmed allelism of Tyr-Cctq1a; albino mice lacking Tyr function had thin corneas. Albino mice also had increased axial length. Because albinism exposes eyes to increased light, the effect of dark-rearing was tested and found to rescue central corneal thickness. In sum, the results point to an epiphenomenon; developmental light exposure interacts with genotype as an important determinate of adult corneal thickness.

ANALYSIS OF THE PLATELET HEMOSTASIS AMONG PREGNANT WOMEN WITH IMMUNE THROMBOCYTOPENIA

Relevance: Thrombocytopenia is a common hematological problem that accompanies pregnancy. From 5% to 12% of pregnancies are complicated by thrombocytopenia. Gestational thrombocytopenia is the leading cause of complications (70-85%). Immune thrombocytopenia (ITP) is the most frequent reason among pre-pregnancy causes of thrombocytopenia and is responsible for 1-4% of all thrombocytopenia cases during pregnancy. Investigation of the functional potential of the thrombocyte link of hemostasis in conditions of a reduced number of thrombocytes is relevant. The purpose of the study was to analyze the platelet link of hemostasis in pregnant women with ITP of varying severity by the method of light aggregometry. Materials and Methods: Eighty-eight women with gestational and 28 with immune thrombocytopenia were undergoing treatment and delivery at the Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine (Kyiv, Ukraine) from September 2018 to February 2021. The platelet link of hemostasis was studied in a group of women with immune thrombocytopenia; six (21.4%) of them had severe thrombocytopenia. Results: In mild and moderate immune thrombocytopenia, we noted a decrease in spontaneous and induced platelet aggregation; in severe immune thrombocytopenia, there was no spontaneous and a decreased induced platelet aggregation. This indicated a reduced potential of platelets to perform their direct function – the formation of a thrombus. Conclusion: Immune thrombocytopenia accounts for most pre-pregnancy conditions causing thrombocytopenia in pregnant women. Light aggregometry is a relevant and indicative way to analyze the aggregative ability of platelets. A multidisciplinary team consisting of an obstetrician-gynecologist, hematologist, anesthesiologist, and neonatologist should be involved in the management of such cases to provide effective obstetric care for this category of pregnant women. Risks for the mother and the fetus/newborn should be assessed throughout the pregnancy, considering clinical and laboratory aspects. Delivery of pregnant women with severe thrombocytopenia should be managed at institutions providing the highest level of obstetric and gynecological care.

Investigating the Compressive Strength Properties of Concrete Using Some Common Ghanaian Ordinary Portland Cements

In a general sense, concrete is made of cementitious material, aggregates and water but the mix productivity is one issues that affect the amount of strength concrete developed. The concrete mix productivity is a direct function of the amount and quality of the cementitious material. The commonest cementitious material used for concrete in Ghana like other countries in the world is the Ordinary Portland Cement. The research sort to investigate the compressive strength properties of concrete made from some common Ghanaian Ordinary Portland Cement brands mostly used in the countries construction industries. The research strategy adopted was experimental. The research was a cross –sectional studies and used laboratory tests to get information on all cements. Cement grade 42.5N, 42.5R and 32.5R were used. A total of one – hundred and eight (108) concrete cubes were made from nine different brands of Ordinary Portland Cement with a mix design of 1:2:4. No admixtures were used in the mix. It was established that, Ordinary Portland Cement Brand E of grade 42.5R has the highest compressive strength after 28 days. Some of the cement brand with grade 32.5R developed better strength than that of grade 42.5R. Based on the experiment conducted, it can be concluded that for the C15 (1:2:4) and C20 compressive strength as per IS 456:2000, Ordinary Portland Cement Brand E and G of grade 42.5R and Ordinary Portland Cement Brand H and J of grade of 32.5R satisfactory meets the requirement. It implies that some of the Ghanaians Portland Cement developed a satisfactory compressive strength and meets the minimum strength attainment after 28 days’ which is 15 N/mm2. Based on the result, it is recommended that Ordinary Portland Cement Brand E of grade 42.5R should be used for most concrete production and Ordinary Portland Cement Brand J of grade 32.5R can also be used for concrete work in the absence of E 42.5R. Citation: Akorli, K. S., Danso, K., Ayarkwa, J. and Acheampong, A. (2021). Investigating the Compressive Strength Properties of Concrete Using Some Common Ghanaian Ordinary Portland Cements. International Journal of Technology and Management Research (IJTMR), Vol. 6 (1): Pp.154-166.[Received: March 13, 2021Accepted: September 1, 2021

Connection Between Maxwell's Equations and the Dirac Equation

Electrically charged particles such as Electrons and Protons carry electric, E, and magnetic, B, fields. In addition to these fields, Quantum Mechanics (QM) endows these particles with an `arcane and spooky' field --- the wavefunction. This wavefunction of QM is not only assumed to be separate but distinct from the electromagnetic field. We herein upend this view by demonstrating otherwise. That is, we demonstrate that the four components of the Dirac wavefunction, can be shown to not only be an intimate, but, a direct function of the electromagnetic field carried by the particle in question. Insofar as unity, depth in our understanding and insight into both Dirac and Maxwell's equations as major pillars of Modern Physics, we believe that this work may very well inch us one-step-closer to the truth.

Heavy metal uptake of near-shore benthic foraminifera during multi-metal culturing experiments

Heavy metal pollution originating from anthropogenic sources, e.g., mining, industry and extensive land use, is increasing in many parts of the world and influences coastal marine environments for a long time. The elevated input of heavy metals into the marine system potentially affects the biota because of their toxicity, persistence and bioaccumulation. An emerging tool for environmental applications is the heavy metal incorporation into foraminiferal tests calcite, which facilitates monitoring of anthropogenic footprints on recent and past environmental systems. The aim of this study is to investigate whether the incorporation of heavy metals in foraminifera is a direct function of their concentration in seawater. Culturing experiments with a mixture of dissolved chromium (Cr), manganese (Mn), nickel (Ni), copper (Cu), zinc (Zn), silver (Ag), cadmium (Cd), tin (Sn), mercury (Hg) and lead (Pb) in artificial seawater were carried out over a wide concentration range to assess the uptake of heavy metals by the near-shore foraminiferal species Ammonia aomoriensis, Ammonia batava and Elphidium excavatum. Seawater analysis exhibited the increasing metal concentrations between culturing phases and revealed high metal concentrations in the beginning of the culturing phases due to the punctual metal addition. Furthermore, a loss of metals during the culturing process was discovered, which lead to a deviation between the expected and the actual concentrations of the metals in seawater. Laser ablation ICP-MS analysis of the newly formed calcite revealed species-specific differences in the incorporation of heavy metals. The foraminiferal calcite of all three species reveals a strong positive correlation with Pb and Ag concentrations in the culturing medium. Ammonia aomoriensis further showed a correlation with Mn and Cu, A. batava with Mn and Hg and E. excavatum with Cr and Ni, and partially also with Hg. Zn, Sn and Cd showed no clear trend for the species studied, which may be caused by the little variation of these metals in seawater. Our calibrations and the calculated partition coefficients render A. aomoriensis, A. batava and E. excavatum as natural archives that enable the direct quantification of metals in polluted and pristine environments. This in turn allows monitoring of the ecosystem status of areas that are potentially under the threat of anthropogenic pollution in order to evaluate contemporary emission reduction measures.