Interdisciplinary and integrated talent training is not only the urgent need of economic, scientific, technological and social development, but also one of the inevitable trends of higher education and teaching reform. Firstly, this paper analyzes and summarizes three types of multidisciplinary talent training modes in American universities, namely, project-based interdisciplinary talent training mode, professional education based interdisciplinary talent training mode and curriculum based interdisciplinary talent training mode. Then, it compares and analyzes four modes of interdisciplinary talent training in Colleges and universities in China, namely interdisciplinary curriculum mode, interdisciplinary project mode, interdisciplinary specialty mode and interdisciplinary degree mode. Finally, it puts forward the design idea of curriculum system of interdisciplinary and integrated talent training mode in China.