scholarly journals Role of Staphylococcus aureus Nasal Colonization in Atopic Dermatitis in Infants

Author(s):  
Ankie Lebon ◽  
Joost A. M. Labout ◽  
Henri A. Verbrugh ◽  
Vincent W. V. Jaddoe ◽  
Albert Hofman ◽  
...  
2018 ◽  
Vol 27 (2) ◽  
pp. 107-112
Author(s):  
Amal A. Wafy ◽  
Wageih S. Elnaghy ◽  
Nashwa El-Far ◽  
Sara A. Hamam ◽  
Mohammed El-Gamasy

2021 ◽  
Vol 30 (1) ◽  
pp. 39-44
Author(s):  
Tamer Mohamed ◽  
Izzedin Abushaikha

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease with multifactorial etiologies, Staphylococcus aureus (S.aureus) and methicillinresistant S.aureus (MRSA) that naturally colonize skin and nose are prevalent among children with AD. Objectives: was to determine the prevalence of S.aureus and MRSA colonization of skin lesions and nose of AD children. Methodology: 40 children diagnosed as AD from Dermatology Clinic of Najran Armed Forces Hospital, Saudi Arabia, were included in the study; separate swabs from skin lesions & nose of each AD patient were tested for S.aureus and MRSA colonization using the conventional culture based Vitek 2 system and the molecular BD Max MRSA XT assay. Results: Using the conventional Vitek 2 system, the prevalence of skin and nasal colonization with S.aureus in AD patients were 25% and 30% respectively while skin and nasal colonization with MRSA were 7.5% and 7.5% respectively, the BD Max MRSA XT assay identified correctly S.aureus with overall 96 % sensitivity, 100 % specificity and 98 % diagnostic accuracy and identified 100 % of MRSA strains. Conclusion: The increase in prevalence of skin and nasal colonization with S.aureus and MRSA among AD children raises the concern about importance of the accurate and rapid molecular diagnostic techniques for preventing the potential risk of MRSA transmission


2020 ◽  
Vol 83 (6) ◽  
pp. 442-449
Author(s):  
Line B. Nørreslet ◽  
Sofie M. Edslev ◽  
Paal S. Andersen ◽  
Frederik Plum ◽  
Jette Holt ◽  
...  

Toxins ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 321 ◽  
Author(s):  
Fabio Seiti Yamada Yoshikawa ◽  
Josenilson Feitosa de Lima ◽  
Maria Notomi Sato ◽  
Yasmin Álefe Leuzzi Ramos ◽  
Valeria Aoki ◽  
...  

Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30–100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease.


2017 ◽  
Vol 12 (14) ◽  
pp. 1327-1334 ◽  
Author(s):  
Simone Saintive ◽  
Eliane Abad ◽  
Dennis de C Ferreira ◽  
Mayra Stambovsky ◽  
Fernanda S Cavalcante ◽  
...  

10.1038/nm991 ◽  
2004 ◽  
Vol 10 (3) ◽  
pp. 243-245 ◽  
Author(s):  
Christopher Weidenmaier ◽  
John F Kokai-Kun ◽  
Sascha A Kristian ◽  
Tanya Chanturiya ◽  
Hubert Kalbacher ◽  
...  

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