Role of Staphylococcus aureus in Atopic Dermatitis

2009 ◽  
pp. 309-319 ◽  
Author(s):  
Peck Ong
2018 ◽  
Vol 27 (2) ◽  
pp. 107-112
Author(s):  
Amal A. Wafy ◽  
Wageih S. Elnaghy ◽  
Nashwa El-Far ◽  
Sara A. Hamam ◽  
Mohammed El-Gamasy

Toxins ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 321 ◽  
Author(s):  
Fabio Seiti Yamada Yoshikawa ◽  
Josenilson Feitosa de Lima ◽  
Maria Notomi Sato ◽  
Yasmin Álefe Leuzzi Ramos ◽  
Valeria Aoki ◽  
...  

Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30–100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease.


Author(s):  
Ankie Lebon ◽  
Joost A. M. Labout ◽  
Henri A. Verbrugh ◽  
Vincent W. V. Jaddoe ◽  
Albert Hofman ◽  
...  

2017 ◽  
Vol 12 (14) ◽  
pp. 1327-1334 ◽  
Author(s):  
Simone Saintive ◽  
Eliane Abad ◽  
Dennis de C Ferreira ◽  
Mayra Stambovsky ◽  
Fernanda S Cavalcante ◽  
...  

2021 ◽  
Vol 11 ◽  
Author(s):  
Patrycja Ogonowska ◽  
Yolanda Gilaberte ◽  
Wioletta Barańska-Rybak ◽  
Joanna Nakonieczna

Atopic dermatitis (AD) patients are massively colonized with Staphylococcus aureus (S. aureus) in lesional and non-lesional skin. A skin infection may become systemic if left untreated. Of interest, the incidence of multi-drug resistant S. aureus (MRSA) in AD patients is higher as compared to a healthy population, which makes treatment even more challenging. Information on the specific genetic background of S. aureus accompanying and/or causing AD flares would be of great importance in terms of possible treatment option development. In this review, we summarized the data on the prevalence of S. aureus in general in AD skin, and the prevalence of specific clones that might be associated with flares of eczema. We put our special interest in the presence and role of staphylococcal enterotoxins as important virulence factors in the epidemiology of AD-derived S. aureus. Also, we summarize the present and potentially useful future anti-staphylococcal treatment.


2019 ◽  
Vol 36 (4) ◽  
pp. 485-491 ◽  
Author(s):  
Hanna Tomczak ◽  
Joanna Wróbel ◽  
Dorota Jenerowicz ◽  
Anna Sadowska-Przytocka ◽  
Magda Wachal ◽  
...  

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e100499 ◽  
Author(s):  
Sung-Wook Hong ◽  
Eun-Byul Choi ◽  
Taek-Ki Min ◽  
Ji-Hyun Kim ◽  
Min-Hye Kim ◽  
...  

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